TY - JOUR AU - Abdeen, Suhaib K AU - Mastandrea, Ignacio AU - Stinchcombe, Nina AU - Puschhof, Jens AU - Elinav, Eran TI - Diet-microbiome interactions in cancer. JO - Cancer cell VL - 43 IS - 4 SN - 1535-6108 CY - Cambridge, Mass. PB - Cell Press M1 - DKFZ-2025-00722 SP - 680-707 PY - 2025 N1 - #EA:D480#LA:D480# / 2025 Apr 14;43(4):680-707 AB - Diet impacts cancer in diverse manners. Multiple nutritional effects on tumors are mediated by dietary modulation of commensals, residing in mucosal surfaces and possibly also within the tumor microenvironment. Mechanistically understanding such diet-microbiome-host interactions may enable to develop precision nutritional interventions impacting cancer development, dissemination, and treatment responses. However, data-driven nutritional strategies integrating diet-microbiome interactions are infrequently incorporated into cancer prevention and treatment schemes. Herein, we discuss how dietary composition affects cancer-related processes through alterations exerted by specific nutrients and complex foods on the microbiome. We highlight how dietary timing, including time-restricted feeding, impacts microbial function in modulating cancer and its therapy. We review existing and experimental nutritional approaches aimed at enhancing microbiome-mediated cancer treatment responsiveness while minimizing adverse effects, and address challenges and prospects in integrating diet-microbiome interactions into precision oncology. Collectively, mechanistically understanding diet-microbiome-host interactomes may enable to achieve a personalized and microbiome-informed optimization of nutritional cancer interventions. KW - cancer (Other) KW - diet (Other) KW - microbiome (Other) KW - microbiota (Other) KW - nutrition (Other) LB - PUB:(DE-HGF)16 C6 - pmid:40185096 DO - DOI:10.1016/j.ccell.2025.03.013 UR - https://inrepo02.dkfz.de/record/300269 ER -