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@ARTICLE{Abdeen:300269,
      author       = {S. K. Abdeen and I. Mastandrea$^*$ and N. Stinchcombe$^*$
                      and J. Puschhof$^*$ and E. Elinav$^*$},
      title        = {{D}iet-microbiome interactions in cancer.},
      journal      = {Cancer cell},
      volume       = {43},
      number       = {4},
      issn         = {1535-6108},
      address      = {Cambridge, Mass.},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2025-00722},
      pages        = {680-707},
      year         = {2025},
      note         = {#EA:D480#LA:D480# / 2025 Apr 14;43(4):680-707},
      abstract     = {Diet impacts cancer in diverse manners. Multiple
                      nutritional effects on tumors are mediated by dietary
                      modulation of commensals, residing in mucosal surfaces and
                      possibly also within the tumor microenvironment.
                      Mechanistically understanding such diet-microbiome-host
                      interactions may enable to develop precision nutritional
                      interventions impacting cancer development, dissemination,
                      and treatment responses. However, data-driven nutritional
                      strategies integrating diet-microbiome interactions are
                      infrequently incorporated into cancer prevention and
                      treatment schemes. Herein, we discuss how dietary
                      composition affects cancer-related processes through
                      alterations exerted by specific nutrients and complex foods
                      on the microbiome. We highlight how dietary timing,
                      including time-restricted feeding, impacts microbial
                      function in modulating cancer and its therapy. We review
                      existing and experimental nutritional approaches aimed at
                      enhancing microbiome-mediated cancer treatment
                      responsiveness while minimizing adverse effects, and address
                      challenges and prospects in integrating diet-microbiome
                      interactions into precision oncology. Collectively,
                      mechanistically understanding diet-microbiome-host
                      interactomes may enable to achieve a personalized and
                      microbiome-informed optimization of nutritional cancer
                      interventions.},
      subtyp        = {Review Article},
      keywords     = {cancer (Other) / diet (Other) / microbiome (Other) /
                      microbiota (Other) / nutrition (Other)},
      cin          = {D480},
      ddc          = {610},
      cid          = {I:(DE-He78)D480-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40185096},
      doi          = {10.1016/j.ccell.2025.03.013},
      url          = {https://inrepo02.dkfz.de/record/300269},
}