TY  - JOUR
AU  - Serpa, Marco
AU  - Brandt, Tobias
AU  - Spohn, Simon K B
AU  - Rimner, Andreas
AU  - Bert, Christoph
TI  - Megavoltage intrafraction monitoring and position uncertainty in gimbaled markerless dynamic tumor tracking treatment of lung tumors.
JO  - Medical physics
VL  - 52
IS  - 6
SN  - 0094-2405
CY  - Hoboken, NJ
PB  - Wiley
M1  - DKFZ-2025-00729
SP  - 4657-4674
PY  - 2025
N1  - 2025 Jun;52(6):4657-4674
AB  - The clinical realization of markerless dynamic tumor tracking (MLDTT) has prompted a new paradigm shift to intrafraction imaging-based quality assurance (QA). During MLDTT treatment using a gimbaled accelerator, the megavoltage (MV) imager serves as an independent system to leverage real-time intrafraction monitoring. Soft-tissue feature tracking has shown promise for tumor localization in confined MV projections, but studies demonstrating its application in clinical MLDTT treatments are scarse.To validate MV image-based dense soft-tissue feature tracking for intrafraction position monitoring of lung tumors during MLDTT stereotactic body radiotherapy (SBRT), and report on the resolved geometric uncertainty.Ten non-small cell lung cancer (NSCLC) patients underwent MLDTT-SBRT using a commercial gimbal-based system. During treatment, beam's-eye-view (BEV) projection images were captured at ∼3 frames s-1 (fps) using the electronic portal imaging device (EPID). MV sequences were streamed to a research workstation and processed off-line using a purpose-built algorithm, the soft-tissue feature tracker (SoFT). Both the tumor and dynamic field aperture position were automatically extracted in the pan and tilt directions of the gimbaled x-ray head, corresponding to the in-plane lateral and longitudinal direction of the imager, and compared to ground truth manual tracking. The success, percentage of fields producing an output, and performance of MV tracking under the presence/absence of anatomy-related obstruction and multi-leaf collimator (MLC) occlusion were quantified, including three-dimensional conformal (3DCRT) and step-and-shoot intensity modulated radiotherapy (IMRT) deliveries. In addition, the geometric uncertainty of MLDTT treatment was estimated as the difference between field aperture and target center position in the BEV. The standard deviation of systematic (Σ) and random (σ) errors were determined.MV tracking was successful for 89.7
KW  - intrafraction monitoring (Other)
KW  - markerless dynamic tumor tracking (Other)
KW  - megavoltage tracking (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40177796
DO  - DOI:10.1002/mp.17740
UR  - https://inrepo02.dkfz.de/record/300276
ER  -