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@ARTICLE{Kanatoula:300282,
      author       = {D. Kanatoula$^*$ and S. A. Wohlfeil$^*$ and J. Jakob and P.
                      Hohenberger and J. Utikal$^*$},
      title        = {{E}ffective treatment of refractory, locally metastatic
                      squamous cell carcinoma of the leg with isolated limb
                      perfusion: a case report with unexpected long
                      progression-free interval.},
      journal      = {Frontiers in oncology},
      volume       = {15},
      issn         = {2234-943X},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2025-00735},
      pages        = {1549683},
      year         = {2025},
      note         = {#EA:A370#LA:A370#},
      abstract     = {Non-melanoma skin cancer (NMSC) is one of the most commonly
                      diagnosed human malignancies and its incidence is steadily
                      increasing. Locally advanced cutaneous squamous cell
                      carcinoma of the extremities that is refractory to standard
                      therapies can be challenging to treat, with amputation of
                      the limb being the ultima ratio treatment. Here we present a
                      67-year-old female patient with metastatic SCC of the leg
                      refractory to standard therapies who was effectively treated
                      with isolated limb perfusion and is free of any sign of
                      relapse since more than 3 years. This case report provides a
                      brief review of the recent literature on isolated limb
                      perfusion and how this effective treatment can preserve the
                      patient's quality of life by avoiding radical surgery and
                      its negative consequences through limb salvage.},
      keywords     = {SCC (Other) / isolated limb perfusion (Other) / rhTNFα
                      (Other) / squamous cell carcinoma (Other) / treatment
                      (Other)},
      cin          = {A370},
      ddc          = {610},
      cid          = {I:(DE-He78)A370-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40190565},
      pmc          = {pmc:PMC11968665},
      doi          = {10.3389/fonc.2025.1549683},
      url          = {https://inrepo02.dkfz.de/record/300282},
}