TY  - JOUR
AU  - Münz, Christian
AU  - Campbell, Grant R
AU  - Esclatine, Audrey
AU  - Faure, Mathias
AU  - Labonte, Patrick
AU  - Lussignol, Marion
AU  - Orvedahl, Anthony
AU  - Altan-Bonnet, Nihal
AU  - Bartenschlager, Ralf
AU  - Beale, Rupert
AU  - Cirone, Mara
AU  - Espert, Lucile
AU  - Jung, Jae
AU  - Leib, David
AU  - Reggiori, Fulvio
AU  - Sanyal, Sumana
AU  - Spector, Stephen A
AU  - Thiel, Volker
AU  - Viret, Christophe
AU  - Wei, Yu
AU  - Wileman, Thomas
AU  - Wodrich, Harald
TI  - Autophagy machinery as exploited by viruses.
JO  - Autophagy reports
VL  - 4
IS  - 1
SN  - 2769-4127
CY  - London
PB  - Taylor & Francis Group
M1  - DKFZ-2025-00756
SP  - 2464986
PY  - 2025
AB  - Viruses adapt and modulate cellular pathways to allow their replication in host cells. The catabolic pathway of macroautophagy, for simplicity referred to as autophagy, is no exception. In this review, we discuss anti-viral functions of both autophagy and select components of the autophagy machinery, and how viruses have evaded them. Some viruses use the membrane remodeling ability of the autophagy machinery to build their replication compartments in the cytosol or efficiently egress from cells in a non-lytic fashion. Some of the autophagy machinery components and their remodeled membranes can even be found in viral particles as envelopes or single membranes around virus packages that protect them during spreading and transmission. Therefore, studies on autophagy regulation by viral infections can reveal functions of the autophagy machinery beyond lysosomal degradation of cytosolic constituents. Furthermore, they can also pinpoint molecular interactions with which the autophagy machinery can most efficiently be manipulated, and this may be relevant to develop effective disease treatments based on autophagy modulation.
KW  - Endosomal damage (Other)
KW  - interferon (Other)
KW  - replication organelle (Other)
KW  - secretory autophagy (Other)
KW  - virophagy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40201908
C2  - pmc:PMC11921968
DO  - DOI:10.1080/27694127.2025.2464986
UR  - https://inrepo02.dkfz.de/record/300306
ER  -