TY  - JOUR
AU  - Gkika, Eleni
AU  - Firat, Elke
AU  - Adebahr, Sonja
AU  - Graf, Erika
AU  - Popp, Ilinca
AU  - Eichhorst, Alexandra
AU  - Radicioni, Gianluca
AU  - Lo, Simon S
AU  - Spohn, Simon K B
AU  - Nestle, Ursula
AU  - Nicolay, Nils H
AU  - Niedermann, Gabriele
AU  - Grosu, Anca-L
AU  - Duda, Dan G
TI  - A prospective study of immune responses in patients with lung metastases treated with stereotactic body radiotherapy with or without concurrent systemic treatment.
JO  - Radiotherapy and oncology
VL  - 207
SN  - 0167-8140
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2025-00770
SP  - 110889
PY  - 2025
N1  - Volume 207, June 2025, 110889
AB  - We evaluated the longitudinal effects of stereotactic body radiotherapy (SBRT) on circulating immune cells.Patients with oligometastatic/oligoprogressive pulmonary lesions were treated with ablative SBRT with (cSBRT) or without (SBRT group) concurrent systemic treatment (chemotherapy or immune checkpoint blockade, ICB) using different fractionation regimes. Immunoprofiling of peripheral blood cells was performed at baseline, during, and at the end of SBRT, and during the first (FU1) and second follow-ups (FU2). The primary endpoint was the increase in CD8+ T cells at FU1 compared to baseline.The study accrued 100 patients, 80 with evaluable samples. At FU1 12 
KW  - Immune modulation (Other)
KW  - Immunomodulatory effects (Other)
KW  - Lung cancer (Other)
KW  - Lung metastases (Other)
KW  - SBRT (Other)
KW  - Stereotactic body radiotherapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40209858
DO  - DOI:10.1016/j.radonc.2025.110889
UR  - https://inrepo02.dkfz.de/record/300324
ER  -