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@ARTICLE{Petersen:300328,
      author       = {S. Petersen and L. Nagel and P. Groß$^*$ and H. de
                      Maissin$^*$ and R. Willing$^*$ and L. Heß$^*$ and J.
                      Mitschke and N. Klemm and J. Treiber and C. A. Müller and
                      S. Knecht and I. Schwartz and M. Weigt and M. Bock$^*$ and
                      D. von Elverfeldt$^*$ and M. Zaitsev$^*$ and E. Y. Chekmenev
                      and J.-B. Hövener and A. Martins$^*$ and F. Schilling$^*$
                      and T. Reinheckel$^*$ and A. Schmidt$^*$},
      title        = {{I}n vivo molecular imaging of breast cancer metabolic
                      heterogeneity using [1-13{C}]pyruvate-d3 hyperpolarized by
                      reversible exchange with parahydrogen.},
      journal      = {Theranostics},
      volume       = {15},
      number       = {9},
      issn         = {1838-7640},
      address      = {Wyoming, NSW},
      publisher    = {Ivyspring},
      reportid     = {DKFZ-2025-00774},
      pages        = {3714 - 3723},
      year         = {2025},
      abstract     = {Metabolic MRI using hyperpolarized (HP) [1-13C]pyruvate is
                      promising for diagnostic medicine, allowing the study of
                      cancer metabolism and early detection of therapy response.
                      However, a possible widespread and routine use requires
                      high-throughput and user-friendly technologies to produce
                      the hyperpolarized media. Methods: Recently, we introduced a
                      fast (6 min) and cost-effective method using Spin-Lock
                      Induced Crossing and Signal Amplification By Reversible
                      Exchange (SLIC-SABRE) at µT fields and a rapid purification
                      to produce biocompatible HP solutions of aqueous pyruvate.
                      In this study, we used SLIC-SABRE to conduct in vivo tumor
                      metabolic imaging in a transgenic breast cancer mouse model
                      (MMTV-PyMT). Results: In agreement with previous HP MRI
                      cancer studies, an elevated lactate metabolism was found in
                      tumors compared to healthy breast tissue, heart, and
                      vasculature, as well as distinct metabolic profiles within
                      different tumor compartments. These findings suggest a
                      potential link between lactate-to-pyruvate ratios and the
                      varying levels of tumor cell proliferation and apoptosis
                      observed by histological analyses. Conclusion: Our results
                      underscore the potential of SABRE to enhance the
                      accessibility and throughput of HP MRI, thereby advancing
                      cancer research and diagnostic oncology.},
      keywords     = {MMTV-PyMT (Other) / SABRE (Other) / hyperpolarization
                      (Other) / metabolic imaging (Other) / parahydrogen (Other)},
      cin          = {FR01 / TU01 / MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331 / I:(DE-He78)TU01-20160331 /
                      I:(DE-He78)MU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40213665},
      pmc          = {pmc:PMC11980672},
      doi          = {10.7150/thno.103272},
      url          = {https://inrepo02.dkfz.de/record/300328},
}