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000300360 1001_ $$00000-0003-4723-1407$$aHayat, Mahtaab$$b0
000300360 245__ $$aGenome-wide association study identifies common variants associated with breast cancer in South African Black women.
000300360 260__ $$a[London]$$bSpringer Nature$$c2025
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000300360 520__ $$aGenome-wide association studies (GWAS) have characterized the contribution of common variants to breast cancer (BC) risk in populations of European ancestry, however GWAS have not been reported in resident African populations. This GWAS included 2485 resident African BC cases and 1101 population matched controls. Two risk loci were identified, located between UNC13C and RAB27A on chromosome 15 (rs7181788, p = 1.01 × 10-08) and in USP22 on chromosome 17 (rs899342, p = 4.62 × 10-08). Several genome-wide significant signals were also detected in hormone receptor subtype analysis. The novel loci did not replicate in BC GWAS data from populations of West Africa ancestry suggesting genetic heterogeneity in different African populations, but further validation of these findings is needed. A European ancestry derived polygenic risk model for BC explained only 0.79% of variance in our data. Larger studies in pan-African populations are needed to further define the genetic contribution to BC risk.
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000300360 650_7 $$0EC 3.1.2.-$$2NLM Chemicals$$aThiolester Hydrolases
000300360 650_7 $$0EC 3.6.5.2$$2NLM Chemicals$$arab GTP-Binding Proteins
000300360 650_2 $$2MeSH$$aHumans
000300360 650_2 $$2MeSH$$aBreast Neoplasms: genetics
000300360 650_2 $$2MeSH$$aBreast Neoplasms: ethnology
000300360 650_2 $$2MeSH$$aFemale
000300360 650_2 $$2MeSH$$aGenome-Wide Association Study
000300360 650_2 $$2MeSH$$aBlack People: genetics
000300360 650_2 $$2MeSH$$aGenetic Predisposition to Disease
000300360 650_2 $$2MeSH$$aPolymorphism, Single Nucleotide
000300360 650_2 $$2MeSH$$aSouth Africa
000300360 650_2 $$2MeSH$$aMiddle Aged
000300360 650_2 $$2MeSH$$aAdult
000300360 650_2 $$2MeSH$$aCase-Control Studies
000300360 650_2 $$2MeSH$$aWhite People: genetics
000300360 650_2 $$2MeSH$$aThiolester Hydrolases: genetics
000300360 650_2 $$2MeSH$$arab GTP-Binding Proteins: genetics
000300360 650_2 $$2MeSH$$aChromosomes, Human, Pair 17: genetics
000300360 650_2 $$2MeSH$$aMultifactorial Inheritance
000300360 7001_ $$00000-0002-3248-4906$$aChen, Wenlong C$$b1
000300360 7001_ $$00000-0003-1334-1819$$aBabb de Villiers, Chantal$$b2
000300360 7001_ $$aHyuck Lee, Sang$$b3
000300360 7001_ $$aCurtis, Charles$$b4
000300360 7001_ $$aNewton, Rob$$b5
000300360 7001_ $$0P:(DE-He78)6b4ebb9791b983b5620c0caaf3468e30$$aWaterboer, Tim$$b6$$udkfz
000300360 7001_ $$aSitas, Freddy$$b7
000300360 7001_ $$aBradshaw, Debbie$$b8
000300360 7001_ $$00000-0002-1955-923X$$aMuchengeti, Mazvita$$b9
000300360 7001_ $$aSingh, Elvira$$b10
000300360 7001_ $$00000-0002-8249-8476$$aLewis, Cathryn M$$b11
000300360 7001_ $$00000-0002-4156-4801$$aRamsay, Michele$$b12
000300360 7001_ $$00000-0003-4178-1838$$aMathew, Christopher G$$b13
000300360 7001_ $$00000-0003-0197-2648$$aBrandenburg, Jean-Tristan$$b14
000300360 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-025-58789-0$$gVol. 16, no. 1, p. 3542$$n1$$p3542$$tNature Communications$$v16$$x2041-1723$$y2025
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