%0 Journal Article
%A Stocker, Hannah
%A Beyer, Léon
%A Trares, Kira
%A Stevenson-Hoare, Joshua
%A Rujescu, Dan
%A Holleczek, Bernd
%A Beyreuther, Konrad
%A Schöttker, Ben
%A Gerwert, Klaus
%A Brenner, Hermann
%T Association of Nonmodifiable Risk Factors With Alzheimer Disease Blood Biomarkers in Community-Dwelling Adults in the ESTHER Study.
%J Neurology
%V 104
%N 9
%@ 0028-3878
%C Philadelphia, Pa.
%I Wolters Kluwer
%M DKFZ-2025-00807
%P e213500
%D 2025
%Z #EA:C070#LA:C070#
%X Dementia-related blood biomarkers are the future of large-scale dementia risk stratification; however, the extent to which phosphorylated tau (P-tau181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP) are associated with nonmodifiable risk factors has yet to be confirmed in the community, and the role of menopause has yet to be investigated. Therefore, the aim of this study was to examine the association of age, sex, APOEe4 status, and menopause, with dementia-related blood biomarker levels (P-tau181, NfL, and GFAP) and rate of change over 11 years in longitudinal biomarker measurements in community-dwelling adults.Within this German population-based Epidemiologische Studie zu Chancen der Verhütung, Früherkennung und optimierten Therapie chronischer Erkrankungen in der älteren Bevölkerung cohort study (n = 9,940), a nested case-control study of 1,026 participants (1:1, without dementia during follow-up: incident dementia during follow-up) aged 50-75 years at baseline followed over 17 years was conducted. Blood biomarker measurements (P-tau181, NfL, and GFAP) were completed in blood from baseline, 8-year, and 11-year follow-ups, and cross-sectional and longitudinal regression analyses were used to assess the association with age, sex, APOEe4, and menopause.The mean age of participants was 64 years, and women accounted for slightly over half (54
%K Humans
%K Female
%K Male
%K Biomarkers: blood
%K Aged
%K Middle Aged
%K Alzheimer Disease: blood
%K Alzheimer Disease: epidemiology
%K Alzheimer Disease: genetics
%K tau Proteins: blood
%K Neurofilament Proteins: blood
%K Risk Factors
%K Glial Fibrillary Acidic Protein: blood
%K Longitudinal Studies
%K Case-Control Studies
%K Independent Living
%K Germany: epidemiology
%K Menopause: blood
%K Cohort Studies
%K Apolipoprotein E4: genetics
%K Age Factors
%K Sex Factors
%K Biomarkers (NLM Chemicals)
%K tau Proteins (NLM Chemicals)
%K Neurofilament Proteins (NLM Chemicals)
%K neurofilament protein L (NLM Chemicals)
%K Glial Fibrillary Acidic Protein (NLM Chemicals)
%K GFAP protein, human (NLM Chemicals)
%K Apolipoprotein E4 (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40239154
%R 10.1212/WNL.0000000000213500
%U https://inrepo02.dkfz.de/record/300574