TY  - JOUR
AU  - Stocker, Hannah
AU  - Beyer, Léon
AU  - Trares, Kira
AU  - Stevenson-Hoare, Joshua
AU  - Rujescu, Dan
AU  - Holleczek, Bernd
AU  - Beyreuther, Konrad
AU  - Schöttker, Ben
AU  - Gerwert, Klaus
AU  - Brenner, Hermann
TI  - Association of Nonmodifiable Risk Factors With Alzheimer Disease Blood Biomarkers in Community-Dwelling Adults in the ESTHER Study.
JO  - Neurology
VL  - 104
IS  - 9
SN  - 0028-3878
CY  - Philadelphia, Pa.
PB  - Wolters Kluwer
M1  - DKFZ-2025-00807
SP  - e213500
PY  - 2025
N1  - #EA:C070#LA:C070#
AB  - Dementia-related blood biomarkers are the future of large-scale dementia risk stratification; however, the extent to which phosphorylated tau (P-tau181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP) are associated with nonmodifiable risk factors has yet to be confirmed in the community, and the role of menopause has yet to be investigated. Therefore, the aim of this study was to examine the association of age, sex, APOEe4 status, and menopause, with dementia-related blood biomarker levels (P-tau181, NfL, and GFAP) and rate of change over 11 years in longitudinal biomarker measurements in community-dwelling adults.Within this German population-based Epidemiologische Studie zu Chancen der Verhütung, Früherkennung und optimierten Therapie chronischer Erkrankungen in der älteren Bevölkerung cohort study (n = 9,940), a nested case-control study of 1,026 participants (1:1, without dementia during follow-up: incident dementia during follow-up) aged 50-75 years at baseline followed over 17 years was conducted. Blood biomarker measurements (P-tau181, NfL, and GFAP) were completed in blood from baseline, 8-year, and 11-year follow-ups, and cross-sectional and longitudinal regression analyses were used to assess the association with age, sex, APOEe4, and menopause.The mean age of participants was 64 years, and women accounted for slightly over half (54
KW  - Humans
KW  - Female
KW  - Male
KW  - Biomarkers: blood
KW  - Aged
KW  - Middle Aged
KW  - Alzheimer Disease: blood
KW  - Alzheimer Disease: epidemiology
KW  - Alzheimer Disease: genetics
KW  - tau Proteins: blood
KW  - Neurofilament Proteins: blood
KW  - Risk Factors
KW  - Glial Fibrillary Acidic Protein: blood
KW  - Longitudinal Studies
KW  - Case-Control Studies
KW  - Independent Living
KW  - Germany: epidemiology
KW  - Menopause: blood
KW  - Cohort Studies
KW  - Apolipoprotein E4: genetics
KW  - Age Factors
KW  - Sex Factors
KW  - Biomarkers (NLM Chemicals)
KW  - tau Proteins (NLM Chemicals)
KW  - Neurofilament Proteins (NLM Chemicals)
KW  - neurofilament protein L (NLM Chemicals)
KW  - Glial Fibrillary Acidic Protein (NLM Chemicals)
KW  - GFAP protein, human (NLM Chemicals)
KW  - Apolipoprotein E4 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40239154
DO  - DOI:10.1212/WNL.0000000000213500
UR  - https://inrepo02.dkfz.de/record/300574
ER  -