TY  - JOUR
AU  - Gerhalter, Teresa
AU  - Marty, Benjamin
AU  - Gast, Lena V
AU  - Roemer, Frank
AU  - Baudin, Pierre-Yves
AU  - Trollmann, Regina
AU  - Uder, Michael
AU  - Carlier, Pierre G
AU  - Nagel, Armin
TI  - Longitudinal Follow-Up of Patients With Duchenne Muscular Dystrophy Using Quantitative 23Na and 1H MRI.
JO  - Journal of cachexia, sarcopenia and muscle
VL  - 16
IS  - 2
SN  - 2190-5991
CY  - Hoboken, NJ
PB  - Wiley
M1  - DKFZ-2025-00811
SP  - e13812
PY  - 2025
N1  - #LA:E020#
AB  - Quantitative muscle MRI commonly evaluates disease activity and muscle wasting in Duchenne muscular dystrophy (DMD). Disturbances in ion homeostasis contribute to DMD pathophysiology, but their relationships with disease progression is unclear. 23Na MRI may provide insights into the disease course and treatment response. This longitudinal study assessed whether sodium levels are elevated in DMD patients regardless of fat fraction (FF) and whether baseline sodium levels influence FF changes over time. Additionally, we quantified the effect of slice selection on measured sodium values.Thirteen DMD boys (age 7.8 ± 2.4 years) underwent MRI of lower leg muscles at 3T at three visits, spaced 6 months apart. We assessed FF for disease progression and water T2, pH, apparent tissue sodium concentration (aTSC), and intracellular-weighted 23Na signal (ICwS) for disease activity. Fourteen healthy boys (age 9.5 ± 1.7 years) underwent the same MRI protocol once. Linear regression and mixed-effect modelling were used to examine sodium level increases and their impact on FF changes.In DMD, muscles with FF < 10
KW  - Humans
KW  - Muscular Dystrophy, Duchenne: diagnostic imaging
KW  - Male
KW  - Child
KW  - Magnetic Resonance Imaging: methods
KW  - Longitudinal Studies
KW  - Follow-Up Studies
KW  - Muscle, Skeletal: diagnostic imaging
KW  - Disease Progression
KW  - Adolescent
KW  - Sodium: metabolism
KW  - Duchenne muscular dystrophy (Other)
KW  - fat fraction (Other)
KW  - muscle imaging (Other)
KW  - quantitative MRI (Other)
KW  - skeletal muscle (Other)
KW  - sodium (Other)
KW  - Sodium (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40254293
DO  - DOI:10.1002/jcsm.13812
UR  - https://inrepo02.dkfz.de/record/300597
ER  -