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@ARTICLE{Chen:300604,
author = {Z. Chen$^*$ and E. Kharazmi and Q. Liang$^*$ and K.
Sundquist and J. Sundquist and M. Fallah$^*$},
title = {{F}amily history of diabetes mellitus and risk of
colorectal cancer: {A} nationwide cohort study.},
journal = {Diabetes research and clinical practice},
volume = {224},
issn = {0168-8227},
address = {Amsterdam [u.a.]},
publisher = {Elsevier Science},
reportid = {DKFZ-2025-00818},
pages = {112187},
year = {2025},
note = {#EA:C120#LA:C120#},
abstract = {Studies have shown the association between personal history
of diabetes mellitus (DM type 1/2) and risk of colorectal
cancer (CRC). This study aims to find the association
between the family history of diabetes and CRC risk.This
large nationwide cohort study leveraged data from several
Swedish nationwide registers (follow-up: 1964-2018) to
compare the risk using standardized incidence ratio
(SIR).11,784,567 individuals (668,348 with DM) were included
and followed for up to 54 years (median = 28 years). Those
with a personal history of DM had a 1.4-fold increased risk
of CRC compared to those without DM (95 $\%$ CI: 1.39-1.45).
However, the addition of a family history of DM in 1 FDR or
≥ 2 FDRs did not significantly alter the increased risk of
early-onset or late-onset CRC.Leveraging one of the world's
largest family-disease datasets, our cohort study confirmed
that personal history of diabetes is associated with an
increased risk of colorectal cancer, but we did not find an
association between a family history of diabetes and risk of
colorectal cancer.},
keywords = {Cohort study (Other) / Colorectal cancer (Other) / Family
history of diabetes (Other) / Nationwide data (Other)},
cin = {C120},
ddc = {610},
cid = {I:(DE-He78)C120-20160331},
pnm = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
pid = {G:(DE-HGF)POF4-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:40252778},
doi = {10.1016/j.diabres.2025.112187},
url = {https://inrepo02.dkfz.de/record/300604},
}