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000300614 1001_ $$aDimopoulou, Olympia$$b0
000300614 245__ $$aMendelian randomization study of sleep traits and risk of colorectal cancer.
000300614 260__ $$a[London]$$bSpringer Nature$$c2025
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000300614 520__ $$aA potential association of endogenous circadian rhythm disruption with risk of cancer development has been suggested, however, epidemiological evidence for the association of sleep traits with colorectal cancer (CRC) is limited and often contradictory. Here we investigated whether genetically predicted chronotype, insomnia and sleep duration are associated with CRC risk in males, females and overall and according to CRC anatomical subsites using Mendelian randomization (MR). The two-sample inverse variance weighted (IVW) method was applied using summary-level data in up to 58,221 CRC cases and 67,694 controls and genome-wide association data of genetic variants for self-reported sleep traits. Secondary analyses using alternative instruments and sensitivity analyses assessing potential violations of MR assumptions were conducted. Genetically predicted morning preference was associated with 13% lower risk of CRC in men (ORIVW = 0.87, 95% CI = 0.78, 0.97, P = 0.01), but not in women or in both sexes combined. Τhis association remained consistent in some, but not all, sensitivity analyses and was very similar for colon and rectal cancer. There was no evidence of an association for any other sleep trait. Overall, this study provides little to no evidence of an association between genetically predicted sleep traits and CRC risk.
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000300614 650_2 $$2MeSH$$aHumans
000300614 650_2 $$2MeSH$$aMendelian Randomization Analysis
000300614 650_2 $$2MeSH$$aColorectal Neoplasms: genetics
000300614 650_2 $$2MeSH$$aColorectal Neoplasms: epidemiology
000300614 650_2 $$2MeSH$$aMale
000300614 650_2 $$2MeSH$$aFemale
000300614 650_2 $$2MeSH$$aSleep: genetics
000300614 650_2 $$2MeSH$$aGenome-Wide Association Study
000300614 650_2 $$2MeSH$$aRisk Factors
000300614 650_2 $$2MeSH$$aPolymorphism, Single Nucleotide
000300614 650_2 $$2MeSH$$aGenetic Predisposition to Disease
000300614 650_2 $$2MeSH$$aCircadian Rhythm: genetics
000300614 650_2 $$2MeSH$$aSleep Initiation and Maintenance Disorders: genetics
000300614 7001_ $$aFuller, Harriett$$b1
000300614 7001_ $$aRichmond, Rebecca C$$b2
000300614 7001_ $$aBouras, Emmanouil$$b3
000300614 7001_ $$aHayes, Bryony$$b4
000300614 7001_ $$aDimou, Niki$$b5
000300614 7001_ $$aMurphy, Neil$$b6
000300614 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b7$$udkfz
000300614 7001_ $$aGsur, Andrea$$b8
000300614 7001_ $$aLe Marchand, Loic$$b9
000300614 7001_ $$aMoreno, Victor$$b10
000300614 7001_ $$aPai, Rish K$$b11
000300614 7001_ $$aPhipps, Amanda I$$b12
000300614 7001_ $$aUm, Caroline Y$$b13
000300614 7001_ $$avan Duijnhoven, Franzel J B$$b14
000300614 7001_ $$aVodicka, Pavel$$b15
000300614 7001_ $$aMartin, Richard M$$b16
000300614 7001_ $$aPlatz, Elizabeth A$$b17
000300614 7001_ $$aGunter, Marc J$$b18
000300614 7001_ $$aPeters, Ulrike$$b19
000300614 7001_ $$aLewis, Sarah J$$b20
000300614 7001_ $$aCao, Yin$$b21
000300614 7001_ $$aTsilidis, Konstantinos K$$b22
000300614 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-024-83693-w$$gVol. 15, no. 1, p. 13478$$n1$$p13478$$tScientific reports$$v15$$x2045-2322$$y2025
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