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000300625 1001_ $$0P:(DE-He78)2a877d9e575a12fba128c39bc22580ec$$aDaugelaite, Klaudija$$b0$$eFirst author$$udkfz
000300625 245__ $$aGranulosa cell transcription is similarly impacted by superovulation and aging and predicts early embryonic trajectories.
000300625 260__ $$a[London]$$bSpringer Nature$$c2025
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000300625 520__ $$aIn vitro fertilization efficiency is limited in part because a fraction of retrieved oocytes fails to fertilize. Accurately evaluating their quality could significantly improve in vitro fertilization efficiency, which would require better understanding how their maturation may be disrupted. Here, we quantitatively investigate the interplay between superovulation and aging in mouse oocytes and their paired granulosa cells using a newly adapted experimental methodology. We test the hypothesis that superovulation disrupts oocyte maturation, revealing the key intercellular communication pathways dysregulated at the transcriptional level by forced hormonal stimulation. We further demonstrate that granulosa cell transcriptional markers can prospectively predict an associated oocyte's early developmental potential. By using naturally ovulated old mice as a non-stimulated reference, we show that aging and superovulation dysregulate similar genes and interact with each other. By comparing mice and human transcriptional responses of granulosa cells, we find that age-related dysregulation of hormonal responses and cell cycle pathways are shared, though substantial divergence exists in other pathways.
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000300625 650_2 $$2MeSH$$aFemale
000300625 650_2 $$2MeSH$$aGranulosa Cells: metabolism
000300625 650_2 $$2MeSH$$aGranulosa Cells: cytology
000300625 650_2 $$2MeSH$$aAnimals
000300625 650_2 $$2MeSH$$aSuperovulation: genetics
000300625 650_2 $$2MeSH$$aSuperovulation: physiology
000300625 650_2 $$2MeSH$$aAging: genetics
000300625 650_2 $$2MeSH$$aAging: physiology
000300625 650_2 $$2MeSH$$aMice
000300625 650_2 $$2MeSH$$aHumans
000300625 650_2 $$2MeSH$$aOocytes: metabolism
000300625 650_2 $$2MeSH$$aOocytes: cytology
000300625 650_2 $$2MeSH$$aOocytes: physiology
000300625 650_2 $$2MeSH$$aTranscription, Genetic
000300625 650_2 $$2MeSH$$aMice, Inbred C57BL
000300625 650_2 $$2MeSH$$aFertilization in Vitro
000300625 650_2 $$2MeSH$$aEmbryonic Development: genetics
000300625 650_2 $$2MeSH$$aGene Expression Regulation, Developmental
000300625 7001_ $$0P:(DE-He78)f6018952ec93bf5131638ee36af98dcb$$aLacour, Perrine$$b1$$eFirst author$$udkfz
000300625 7001_ $$0P:(DE-He78)4eb274593fde2b15697a325349d89aa4$$aWinkler, Ivana$$b2$$eFirst author$$udkfz
000300625 7001_ $$0P:(DE-He78)6154bf685be3d3443132aea60a61e4c3$$aKoch, Marie-Luise$$b3$$udkfz
000300625 7001_ $$0P:(DE-He78)3d9a9410b62194888d8451351f2ed5d2$$aSchneider, Anja$$b4$$udkfz
000300625 7001_ $$0P:(DE-He78)1088dd9d9cfbe8e797ae362bcdc691f3$$aSchneider, Nina$$b5$$udkfz
000300625 7001_ $$0P:(DE-He78)c1ed6153666182a9dd6635bc4a077f0f$$aCoraggio, Francesca$$b6$$udkfz
000300625 7001_ $$aTolkachov, Alexander$$b7
000300625 7001_ $$aNguyen, Xuan Phuoc$$b8
000300625 7001_ $$00000-0002-6863-2755$$aVilkaite, Adriana$$b9
000300625 7001_ $$00000-0003-4409-4697$$aRehnitz, Julia$$b10
000300625 7001_ $$0P:(DE-He78)4c21317940f3ec566480ebcdcff3e00c$$aOdom, Duncan$$b11$$udkfz
000300625 7001_ $$00000-0002-3890-7658$$aGoncalves, Angela$$b12$$eFirst author
000300625 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-025-58451-9$$gVol. 16, no. 1, p. 3658$$n1$$p3658$$tNature Communications$$v16$$x2041-1723$$y2025
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