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@ARTICLE{Daugelaite:300625,
      author       = {K. Daugelaite$^*$ and P. Lacour$^*$ and I. Winkler$^*$ and
                      M.-L. Koch$^*$ and A. Schneider$^*$ and N. Schneider$^*$ and
                      F. Coraggio$^*$ and A. Tolkachov and X. P. Nguyen and A.
                      Vilkaite and J. Rehnitz and D. Odom$^*$ and A.
                      Goncalves$^*$},
      title        = {{G}ranulosa cell transcription is similarly impacted by
                      superovulation and aging and predicts early embryonic
                      trajectories.},
      journal      = {Nature Communications},
      volume       = {16},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2025-00839},
      pages        = {3658},
      year         = {2025},
      note         = {#EA:B270#EA:C220#LA:B270#},
      abstract     = {In vitro fertilization efficiency is limited in part
                      because a fraction of retrieved oocytes fails to fertilize.
                      Accurately evaluating their quality could significantly
                      improve in vitro fertilization efficiency, which would
                      require better understanding how their maturation may be
                      disrupted. Here, we quantitatively investigate the interplay
                      between superovulation and aging in mouse oocytes and their
                      paired granulosa cells using a newly adapted experimental
                      methodology. We test the hypothesis that superovulation
                      disrupts oocyte maturation, revealing the key intercellular
                      communication pathways dysregulated at the transcriptional
                      level by forced hormonal stimulation. We further demonstrate
                      that granulosa cell transcriptional markers can
                      prospectively predict an associated oocyte's early
                      developmental potential. By using naturally ovulated old
                      mice as a non-stimulated reference, we show that aging and
                      superovulation dysregulate similar genes and interact with
                      each other. By comparing mice and human transcriptional
                      responses of granulosa cells, we find that age-related
                      dysregulation of hormonal responses and cell cycle pathways
                      are shared, though substantial divergence exists in other
                      pathways.},
      keywords     = {Female / Granulosa Cells: metabolism / Granulosa Cells:
                      cytology / Animals / Superovulation: genetics /
                      Superovulation: physiology / Aging: genetics / Aging:
                      physiology / Mice / Humans / Oocytes: metabolism / Oocytes:
                      cytology / Oocytes: physiology / Transcription, Genetic /
                      Mice, Inbred C57BL / Fertilization in Vitro / Embryonic
                      Development: genetics / Gene Expression Regulation,
                      Developmental},
      cin          = {B270 / C220},
      ddc          = {500},
      cid          = {I:(DE-He78)B270-20160331 / I:(DE-He78)C220-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40246835},
      pmc          = {pmc:PMC12006393},
      doi          = {10.1038/s41467-025-58451-9},
      url          = {https://inrepo02.dkfz.de/record/300625},
}