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@ARTICLE{Onyedibe:300631,
      author       = {M. C. C. Onyedibe$^*$ and M. Schmidt$^*$ and P. Bizer$^*$
                      and P. Zimmer and K. Steindorf$^*$},
      title        = {{S}ubjective and {O}bjective {C}ancer-{R}elated {C}ognitive
                      {I}mpairments {A}mong {S}ystemic and {R}adiation
                      {T}herapy-{N}aïve {F}emale {C}ancer {P}atients.},
      journal      = {Cancer medicine},
      volume       = {14},
      number       = {8},
      issn         = {2045-7634},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2025-00845},
      pages        = {e70908},
      year         = {2025},
      note         = {#EA:C110#LA:C110#},
      abstract     = {Cancer-related cognitive impairment (CRCI) is a frequent
                      and burdensome problem that is still insufficiently
                      understood and managed. We investigated subjective and
                      objective measures of CRCI, as recommended by the
                      International Cancer and Cognition Task Force (ICCTF) in
                      cancer patients prior to systemic or radiation therapy with
                      respect to potential influencing or associated psychosocial,
                      demographic, or lifestyle factors.Female patients with
                      breast or gynecological tumors (n = 239, mean age = 55.5, SD
                      = 11.6) prior to any systemic or radiation therapy completed
                      validated subjective (FACT-Cog: perceived cognitive
                      impairment [PCI], perceived cognitive ability [PCA], impact
                      on quality of life [IQoL]) and objective measures of CRCI
                      (Trail Making Test [TMT-A and -B], Controlled Oral Word
                      Association Test [COWA], and Hopkins Verbal Learning
                      Test-Revised [HVLT-R]). Association with cross-sectionally
                      assessed age, body mass index, education, smoking, alcohol
                      intake, sleep problems, social support, anxiety, and pain
                      was investigated using multiple linear regression models.A
                      quarter $(25.1\%)$ of patients showed indication for CRCI
                      based on the PCI score. Subjective and objective CRCI
                      measures showed no or only weak correlations, also when
                      adjusting for age and education (partial Spearman
                      correlations with each other, all |r| ≤ 0.21). Anxiety,
                      sleep problems, and pain were significantly associated with
                      low subjective cognitive function (PCI, PCA, and IQoL). Poor
                      objective cognitive values (TMT, COWA, and HVLT-R) were
                      mainly determined by higher age and lower
                      education.Cancer-related cognitive impairment is not solely
                      (chemo-)therapy-induced but may be triggered or influenced
                      by anxiety, sleep problems, and pain. Addressing these
                      issues early in the treatment phase could potentially
                      alleviate perceived CRCI. The ICCTF-recommended
                      neuropsychological tests do not adequately capture this CRCI
                      prior to systemic or radiation therapy, but could serve as
                      complementary tools to monitor cognitive changes over time,
                      independent of psychosocial influences.},
      keywords     = {Humans / Female / Middle Aged / Quality of Life / Aged /
                      Cognitive Dysfunction: etiology / Cognitive Dysfunction:
                      epidemiology / Cognitive Dysfunction: diagnosis / Cognitive
                      Dysfunction: psychology / Adult / Breast Neoplasms:
                      complications / Breast Neoplasms: psychology / Breast
                      Neoplasms: therapy / Cross-Sectional Studies / Genital
                      Neoplasms, Female: complications / Genital Neoplasms,
                      Female: psychology / Genital Neoplasms, Female: therapy /
                      Neuropsychological Tests / anxiety (Other) / breast cancer
                      (Other) / cancer‐related cognitive impairment (Other) /
                      neuropsychological tests (Other) / sleep problem (Other)},
      cin          = {C110},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40259875},
      doi          = {10.1002/cam4.70908},
      url          = {https://inrepo02.dkfz.de/record/300631},
}