%0 Journal Article
%A Lazareva, Olga
%A Riediger, Anja Lisa
%A Stegle, Oliver
%A Sültmann, Holger
%A Hohenfellner, Markus
%A Görtz, Magdalena
%T Integrative analysis of blood biomarkers and clinical variables improves early detection of aggressive prostate cancer.
%J Scientific reports
%V 15
%N 1
%@ 2045-2322
%C [London]
%I Springer Nature
%M DKFZ-2025-00862
%P 14071
%D 2025
%Z #EA:E250#EA:B260#LA:E250#
%X Aggressive prostate cancer (PC) represents a significant health concern. Conventional screening methods, primarily based on prostate-specific antigen (PSA) levels, lack specificity, leading to an urgent need for more accurate diagnostic tools. This study investigates whether integrating clinical and routine blood laboratory parameters can improve the early non-invasive prediction of aggressive PC. In a pilot study of 578 patients with suspicion of PC, 28 laboratory values alongside data on family history, diet, and lifestyle were analyzed. A logistic regression classifier was developed, with model performance evaluated using repeated k-fold cross-validation on the complete dataset (n = 282). Participants were categorized into healthy, moderate PC (ISUP 1-2), and aggressive PC (ISUP 3-5). Significant associations were found between PC aggressiveness and lower levels of androstenedione, dehydroepiandrosterone-sulfate (DHEA-S) and free PSA
%K Humans
%K Male
%K Prostatic Neoplasms: blood
%K Prostatic Neoplasms: diagnosis
%K Prostatic Neoplasms: pathology
%K Biomarkers, Tumor: blood
%K Middle Aged
%K Aged
%K Early Detection of Cancer: methods
%K Prostate-Specific Antigen: blood
%K Pilot Projects
%K Androstenedione (Other)
%K Dehydroepiandrosterone-sulfate (Other)
%K Early detection of cancer (Other)
%K Prostate-specific antigen (Other)
%K Prostatic neoplasms (Other)
%K Sex hormone binding globulin (Other)
%K Biomarkers, Tumor (NLM Chemicals)
%K Prostate-Specific Antigen (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40269068
%R 10.1038/s41598-025-98980-3
%U https://inrepo02.dkfz.de/record/300668