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@ARTICLE{TrewinNybrten:300694,
author = {C. B. Trewin-Nybråten and S. Leithe and T. Paulsen and H.
Langseth and R. T. Fortner$^*$},
title = {{O}varian cancer survival by residual disease following
cytoreductive surgery: a nationwide study in {N}orway.},
journal = {British journal of cancer},
volume = {132},
number = {12},
issn = {0007-0920},
address = {Edinburgh},
publisher = {Nature Publ. Group},
reportid = {DKFZ-2025-00874},
pages = {1158-1166},
year = {2025},
note = {#LA:C020# / 2025 Jun;132(12):1158-1166},
abstract = {Residual disease (RD) following cytoreductive surgery is
prognostic for epithelial ovarian cancer (EOC) patients. Few
studies have evaluated RD and survival by tumor histotype
and across continuous RD diameter.2608 individuals with
stages III-IV invasive EOC diagnosed between 2013 and 2022
were identified using the Cancer Registry of Norway. In
flexible parametric models, we compared excess mortality
comparing RD versus no macroscopic residual disease (NMRD);
systemic anti-cancer therapy was evaluated in a sub-cohort
from 2019. Excess mortality was assessed across continuous
RD size using restricted cubic splines.Among 1849 patients
with cytoreductive surgery, survival was worse for
individuals with RD (vs. NMRD), excess hazard ratio (EHR) =
2.62 $(95\%$ confidence interval = (2.27-3.01)); no
heterogeneity was observed by histotype (p = 0.21). Patients
with 0.1-0.4 cm RD had 2-fold higher risk of death (EHR =
2.09 (1.63-2.68)) relative to women with NMRD; ~3-fold
higher risk was observed for all other categories (e.g.,
0.5-0.9 cm, EHR = 2.97 (2.26-3.89); 3.0-20 cm, 2.75
(2.05-3.70)). No significant difference in three-year
survival was observed across continuous RD diameter (p ≥
0.17). NMRD was associated with better survival regardless
of neoadjuvant chemotherapy.Achieving NMRD resulted in the
best survival outcomes. Among patients with RD, we observed
no significant difference in survival by RD diameter.},
cin = {C020},
ddc = {610},
cid = {I:(DE-He78)C020-20160331},
pnm = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
pid = {G:(DE-HGF)POF4-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:40287590},
doi = {10.1038/s41416-025-03018-0},
url = {https://inrepo02.dkfz.de/record/300694},
}