%0 Journal Article
%A Yapici, F Isil
%A Seidel, Eric
%A Dahlhaus, Alina
%A Weber, Josephine
%A Schmidt, Christina
%A de Britto Chaves Filho, Adriano
%A Yang, Ming
%A Nenchova, Maria
%A Güngör, Emre
%A Stroh, Jenny
%A Kotouza, Ioanna
%A Beck, Julia
%A Abdallah, Ali T
%A Lackmann, Jan-Wilm
%A Bebber, Christina M
%A Androulidaki, Ariadne
%A Kreuzaler, Peter
%A Schulze, Almut
%A Frezza, Christian
%A von Karstedt, Silvia
%T An atlas of ferroptosis-induced secretomes.
%J Cell death and differentiation
%V nn
%@ 1350-9047
%C [London]
%I Springer Nature
%M DKFZ-2025-00882
%P nn
%D 2025
%Z epub / DKFZ-ZMBH Alliance
%X Cells undergoing regulated necrosis systemically communicate with the immune system via the release of protein and non-protein secretomes. Ferroptosis is a recently described iron-dependent type of regulated necrosis driven by massive lipid peroxidation. While membrane rupture occurs during ferroptosis, a comprehensive appraisal of ferroptotic secretomes and their potential biological activity has been lacking. Here, we apply a multi-omics approach to provide an atlas of ferroptosis-induced secretomes and reveal a novel function in macrophage priming. Proteins with assigned DAMP and innate immune system function, such as MIF, heat shock proteins (HSPs), and chaperones, were released from ferroptotic cells. Non-protein secretomes with assigned inflammatory function contained oxylipins as well as TCA- and methionine-cycle metabolites. Interestingly, incubation of bone marrow-derived macrophages (BMDMs) with ferroptotic supernatants induced transcriptional reprogramming consistent with priming. Indeed, exposure to ferroptotic supernatants enhanced LPS-induced cytokine production. These results define a catalog of ferroptosis-induced secretomes and identify a biological activity in macrophage priming with important implications for the fine-tuning of inflammatory processes.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40281125
%R 10.1038/s41418-025-01517-4
%U https://inrepo02.dkfz.de/record/300702