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000300702 1001_ $$00009-0004-9298-8315$$aYapici, F Isil$$b0
000300702 245__ $$aAn atlas of ferroptosis-induced secretomes.
000300702 260__ $$a[London]$$bSpringer Nature$$c2025
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000300702 520__ $$aCells undergoing regulated necrosis systemically communicate with the immune system via the release of protein and non-protein secretomes. Ferroptosis is a recently described iron-dependent type of regulated necrosis driven by massive lipid peroxidation. While membrane rupture occurs during ferroptosis, a comprehensive appraisal of ferroptotic secretomes and their potential biological activity has been lacking. Here, we apply a multi-omics approach to provide an atlas of ferroptosis-induced secretomes and reveal a novel function in macrophage priming. Proteins with assigned DAMP and innate immune system function, such as MIF, heat shock proteins (HSPs), and chaperones, were released from ferroptotic cells. Non-protein secretomes with assigned inflammatory function contained oxylipins as well as TCA- and methionine-cycle metabolites. Interestingly, incubation of bone marrow-derived macrophages (BMDMs) with ferroptotic supernatants induced transcriptional reprogramming consistent with priming. Indeed, exposure to ferroptotic supernatants enhanced LPS-induced cytokine production. These results define a catalog of ferroptosis-induced secretomes and identify a biological activity in macrophage priming with important implications for the fine-tuning of inflammatory processes.
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000300702 7001_ $$00000-0003-3334-3950$$aSeidel, Eric$$b1
000300702 7001_ $$00000-0001-9055-0695$$aDahlhaus, Alina$$b2
000300702 7001_ $$aWeber, Josephine$$b3
000300702 7001_ $$00000-0002-3867-0881$$aSchmidt, Christina$$b4
000300702 7001_ $$0P:(DE-He78)5c3fb2db99f4cb5ee64d78f2d458d032$$ade Britto Chaves Filho, Adriano$$b5$$udkfz
000300702 7001_ $$aYang, Ming$$b6
000300702 7001_ $$00009-0008-2522-9641$$aNenchova, Maria$$b7
000300702 7001_ $$00009-0008-7244-1469$$aGüngör, Emre$$b8
000300702 7001_ $$aStroh, Jenny$$b9
000300702 7001_ $$aKotouza, Ioanna$$b10
000300702 7001_ $$aBeck, Julia$$b11
000300702 7001_ $$aAbdallah, Ali T$$b12
000300702 7001_ $$00000-0001-8182-8034$$aLackmann, Jan-Wilm$$b13
000300702 7001_ $$00000-0002-7841-7493$$aBebber, Christina M$$b14
000300702 7001_ $$aAndroulidaki, Ariadne$$b15
000300702 7001_ $$00000-0001-8684-9424$$aKreuzaler, Peter$$b16
000300702 7001_ $$0P:(DE-He78)94ae391f53fb9285e1b68f9930615af1$$aSchulze, Almut$$b17$$udkfz
000300702 7001_ $$aFrezza, Christian$$b18
000300702 7001_ $$00000-0002-7816-5919$$avon Karstedt, Silvia$$b19
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