TY  - JOUR
AU  - Yapici, F Isil
AU  - Seidel, Eric
AU  - Dahlhaus, Alina
AU  - Weber, Josephine
AU  - Schmidt, Christina
AU  - de Britto Chaves Filho, Adriano
AU  - Yang, Ming
AU  - Nenchova, Maria
AU  - Güngör, Emre
AU  - Stroh, Jenny
AU  - Kotouza, Ioanna
AU  - Beck, Julia
AU  - Abdallah, Ali T
AU  - Lackmann, Jan-Wilm
AU  - Bebber, Christina M
AU  - Androulidaki, Ariadne
AU  - Kreuzaler, Peter
AU  - Schulze, Almut
AU  - Frezza, Christian
AU  - von Karstedt, Silvia
TI  - An atlas of ferroptosis-induced secretomes.
JO  - Cell death and differentiation
VL  - nn
SN  - 1350-9047
CY  - [London]
PB  - Springer Nature
M1  - DKFZ-2025-00882
SP  - nn
PY  - 2025
N1  - epub / DKFZ-ZMBH Alliance
AB  - Cells undergoing regulated necrosis systemically communicate with the immune system via the release of protein and non-protein secretomes. Ferroptosis is a recently described iron-dependent type of regulated necrosis driven by massive lipid peroxidation. While membrane rupture occurs during ferroptosis, a comprehensive appraisal of ferroptotic secretomes and their potential biological activity has been lacking. Here, we apply a multi-omics approach to provide an atlas of ferroptosis-induced secretomes and reveal a novel function in macrophage priming. Proteins with assigned DAMP and innate immune system function, such as MIF, heat shock proteins (HSPs), and chaperones, were released from ferroptotic cells. Non-protein secretomes with assigned inflammatory function contained oxylipins as well as TCA- and methionine-cycle metabolites. Interestingly, incubation of bone marrow-derived macrophages (BMDMs) with ferroptotic supernatants induced transcriptional reprogramming consistent with priming. Indeed, exposure to ferroptotic supernatants enhanced LPS-induced cytokine production. These results define a catalog of ferroptosis-induced secretomes and identify a biological activity in macrophage priming with important implications for the fine-tuning of inflammatory processes.
LB  - PUB:(DE-HGF)16
C6  - pmid:40281125
DO  - DOI:10.1038/s41418-025-01517-4
UR  - https://inrepo02.dkfz.de/record/300702
ER  -