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| 001 | 300702 | ||
| 005 | 20250504020334.0 | ||
| 024 | 7 | _ | |a 10.1038/s41418-025-01517-4 |2 doi |
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| 100 | 1 | _ | |a Yapici, F Isil |0 0009-0004-9298-8315 |b 0 |
| 245 | _ | _ | |a An atlas of ferroptosis-induced secretomes. |
| 260 | _ | _ | |a [London] |c 2025 |b Springer Nature |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Cells undergoing regulated necrosis systemically communicate with the immune system via the release of protein and non-protein secretomes. Ferroptosis is a recently described iron-dependent type of regulated necrosis driven by massive lipid peroxidation. While membrane rupture occurs during ferroptosis, a comprehensive appraisal of ferroptotic secretomes and their potential biological activity has been lacking. Here, we apply a multi-omics approach to provide an atlas of ferroptosis-induced secretomes and reveal a novel function in macrophage priming. Proteins with assigned DAMP and innate immune system function, such as MIF, heat shock proteins (HSPs), and chaperones, were released from ferroptotic cells. Non-protein secretomes with assigned inflammatory function contained oxylipins as well as TCA- and methionine-cycle metabolites. Interestingly, incubation of bone marrow-derived macrophages (BMDMs) with ferroptotic supernatants induced transcriptional reprogramming consistent with priming. Indeed, exposure to ferroptotic supernatants enhanced LPS-induced cytokine production. These results define a catalog of ferroptosis-induced secretomes and identify a biological activity in macrophage priming with important implications for the fine-tuning of inflammatory processes. |
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| 700 | 1 | _ | |a Seidel, Eric |0 0000-0003-3334-3950 |b 1 |
| 700 | 1 | _ | |a Dahlhaus, Alina |0 0000-0001-9055-0695 |b 2 |
| 700 | 1 | _ | |a Weber, Josephine |b 3 |
| 700 | 1 | _ | |a Schmidt, Christina |0 0000-0002-3867-0881 |b 4 |
| 700 | 1 | _ | |a de Britto Chaves Filho, Adriano |0 P:(DE-He78)5c3fb2db99f4cb5ee64d78f2d458d032 |b 5 |u dkfz |
| 700 | 1 | _ | |a Yang, Ming |b 6 |
| 700 | 1 | _ | |a Nenchova, Maria |0 0009-0008-2522-9641 |b 7 |
| 700 | 1 | _ | |a Güngör, Emre |0 0009-0008-7244-1469 |b 8 |
| 700 | 1 | _ | |a Stroh, Jenny |b 9 |
| 700 | 1 | _ | |a Kotouza, Ioanna |b 10 |
| 700 | 1 | _ | |a Beck, Julia |b 11 |
| 700 | 1 | _ | |a Abdallah, Ali T |b 12 |
| 700 | 1 | _ | |a Lackmann, Jan-Wilm |0 0000-0001-8182-8034 |b 13 |
| 700 | 1 | _ | |a Bebber, Christina M |0 0000-0002-7841-7493 |b 14 |
| 700 | 1 | _ | |a Androulidaki, Ariadne |b 15 |
| 700 | 1 | _ | |a Kreuzaler, Peter |0 0000-0001-8684-9424 |b 16 |
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| 700 | 1 | _ | |a Frezza, Christian |b 18 |
| 700 | 1 | _ | |a von Karstedt, Silvia |0 0000-0002-7816-5919 |b 19 |
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