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@ARTICLE{Wankhede:300706,
      author       = {D. Wankhede$^*$ and N. Halama$^*$ and M. Kloor$^*$ and D.
                      Edelmann$^*$ and H. Brenner$^*$ and M. Hoffmeister$^*$},
      title        = {{P}rognostic {V}alue of {CD}8+ {T} {C}ells at the
                      {I}nvasive {M}argin {I}s {C}omparable to the {I}mmune
                      {S}core in {N}onmetastatic {C}olorectal {C}ancer: {A}
                      {P}rospective {M}ulticentric {C}ohort {S}tudy.},
      journal      = {Clinical cancer research},
      volume       = {31},
      number       = {9},
      issn         = {1078-0432},
      address      = {Philadelphia, Pa. [u.a.]},
      publisher    = {AACR},
      reportid     = {DKFZ-2025-00886},
      pages        = {1711-1718},
      year         = {2025},
      note         = {#EA:C070#LA:C070# / 2025 May 1;31(9):1711-1718 / D196
                      =Translationale Immuntherapie vormals D240},
      abstract     = {The Immunoscore predicts colorectal cancer prognosis but
                      faces adoption barriers because of complex software and
                      reimbursement issues. This study used open-source methods to
                      explore a simplified prognostic model in nonmetastatic
                      colorectal cancer by focusing on single T-cell markers.A
                      multicentric prospective cohort study in patients with
                      nonmetastatic colorectal cancer assessed CD3+ and CD8+
                      tumor-infiltrating lymphocytes (TIL) in the invasive margin
                      (IM) and tumor core (TC) using QuPath. An immune cell score
                      (ICS), based on TIL densities (CD3-IM, CD8-IM, CD3-TC, and
                      CD8-TC), was calculated similarly to the Immunoscore. A
                      split sample approach (70:30) estimated adjusted HRs for
                      cancer-specific survival in training and validation sets.
                      Classification and regression tree analysis identified the
                      most prognostic TIL, and its model was compared with an ICS
                      model for performance (Brier score) and discrimination
                      (concordance probability estimate).Over a median follow-up
                      of 9.0 years, 203 colorectal cancer-specific deaths occurred
                      among 1,260 patients. Classification and regression
                      tree-selected CD8-IM was the most prognostic TIL at a cutoff
                      of 231 cells/mm2. Patients with high CD8-IM had better
                      cancer-specific survival than low CD8-IM in both training
                      (HR 0.58, $95\%$ confidence interval, 0.40-0.84) and
                      validation sets (HR 0.35, $95\%$ confidence interval,
                      0.21-0.60). Brier scores of CD8-IM and ICS survival models
                      were comparable in both training and validation cohorts,
                      whereas the survival discrimination of CD8-IM slightly
                      outperformed the ICS in the validation set (concordance
                      probability estimate: CD8-IM: 0.748; ICS: 0.730).CD8-IM
                      alone provided prognostic information comparable with the
                      ICS. Simplified, cost-effective TIL assessments could
                      improve clinical translation and guide adjuvant therapy in
                      early-stage colorectal cancer.},
      cin          = {C070 / D196 / D470 / C060 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)D196-20160331 /
                      I:(DE-He78)D470-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40293274},
      doi          = {10.1158/1078-0432.CCR-24-3275},
      url          = {https://inrepo02.dkfz.de/record/300706},
}