TY  - JOUR
AU  - Gallinnis, Patrik Jan
AU  - Möller, Rika
AU  - Ljimani, Alexandra
AU  - Cabuk, Yusuf
AU  - Scheuer, Marie
AU  - Böttger, Charlotte
AU  - Liang, Cecilia
AU  - Nagel, Armin
AU  - Bechler, Eric
AU  - Wittsack, Hans-Jörg
AU  - Müller-Lutz, Anja
AU  - Kamp, Benedikt
TI  - Comparison of twelve-layer concentric object (TLCO) and Line segmentations methods to determine the renal corticomedullary sodium gradient (CMSG) with a 3 T MRI.
JO  - Magnetic resonance in medicine
VL  - 94
IS  - 3
SN  - 1522-2594
CY  - New York, NY [u.a.]
PB  - Wiley-Liss
M1  - DKFZ-2025-00891
SP  - 1318-1325
PY  - 2025
N1  - 2025 Sep;94(3):1318-1325
AB  - 23Na MRI is a functional imaging technique that facilitates measurements of the renal corticomedullary sodium gradient (CMSG). The CMSG can be determined by a region of interest (ROI) in the renal parenchyma along the corticomedullary axis (Line method) or by dividing the renal parenchyma into concentric layers, using the twelve-layer concentric objects (TLCO) method. The aim of this study was to investigate the differences, strengths, and weaknesses in determining the CMSG using these methods.Ten healthy volunteers were examined on a 3 T MRI-system. 23Na images were acquired using a double-tuned 23Na/1H surface coil and a golden angle (GA) density-adapted 3D radial (DA-3D-RAD) sequence. The CMSG was determined with the Line and TLCO methods. Intra- and inter-reader analyses were performed by two radiologists.The evaluated CMSG by the two methods does not differ statistically significantly. Compared to the Line method, the TLCO method provides improved results in terms of reliability, precision, reproducibility, and concordance in intra- and inter-reader analyses. A CMSG of (6.7 ± 2.6) mM/mm was determined using the TLCO method in the segmentation process with the lowest standard deviation.The TLCO method shows superior performance in determining the CMSG compared to the Line method. Accordingly, the use of the TLCO method is recommended for future renal CMSG studies.
KW  - corticomedullary 23Na gradient (Other)
KW  - kidney sodium MRI (Other)
KW  - sodium MRI23Na MR imaging (Other)
KW  - twelve‐layer concentric objects (TLCO) method (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40294090
DO  - DOI:10.1002/mrm.30525
UR  - https://inrepo02.dkfz.de/record/300711
ER  -