%0 Journal Article
%A Zwicker, Felix
%A Raether, Luis-Philipp
%A Klepper, Rudolf
%A Hauswald, Henrik
%A Hoefel, Sebastian
%A Huber, Peter
%A Debus, Jürgen
%A Schempp, Michael
%T Long-term Outcomes of Helical Tomotherapy in Lymph Node-positive Breast Cancer Following Breast-conserving Surgery.
%J Anticancer research
%V 45
%N 5
%@ 0250-7005
%C Kapandriti, Attiki, Greece
%I International Institute of Anticancer Research
%M DKFZ-2025-00901
%P 2025 - 2040
%D 2025
%Z #EA:E055#
%X Adjuvant radiotherapy is an integral component of the interdisciplinary curative treatment of lymph node-positive breast cancer. We investigated long-term clinical outcomes of helical tomotherapy following breast-conserving surgery.This single-center analysis included 80 female patients with breast cancer stages T1-T4 and lymph node metastasis (N1-N3) who underwent breast-conserving surgery, sentinel node biopsy, and/or axillary lymph node dissection. Patients received adjuvant fractionated radiation therapy to the whole breast and regional lymph node areas using helical tomotherapy. Boost irradiation was delivered sequentially or through the simultaneous integrated boost technique. Local control (LC), metastasis, survival, toxicity, and secondary malignancy rates were retrospectively analyzed.The mean follow-up duration was 75 months. The 5- and 8-year overall survival rates were 89.4
%K Humans
%K Female
%K Breast Neoplasms: radiotherapy
%K Breast Neoplasms: pathology
%K Breast Neoplasms: surgery
%K Breast Neoplasms: mortality
%K Middle Aged
%K Mastectomy, Segmental
%K Adult
%K Aged
%K Lymphatic Metastasis: radiotherapy
%K Radiotherapy, Intensity-Modulated: methods
%K Radiotherapy, Intensity-Modulated: adverse effects
%K Radiotherapy, Adjuvant: adverse effects
%K Radiotherapy, Adjuvant: methods
%K Retrospective Studies
%K Treatment Outcome
%K Lymph Nodes: pathology
%K Sentinel Lymph Node Biopsy
%K Lymph Node Excision
%K Helical tomotherapy (Other)
%K adjuvant radiotherapy (Other)
%K lymph node-positive breast cancer (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40295057
%R 10.21873/anticanres.17577
%U https://inrepo02.dkfz.de/record/300741