TY  - JOUR
AU  - Zwicker, Felix
AU  - Raether, Luis-Philipp
AU  - Klepper, Rudolf
AU  - Hauswald, Henrik
AU  - Hoefel, Sebastian
AU  - Huber, Peter
AU  - Debus, Jürgen
AU  - Schempp, Michael
TI  - Long-term Outcomes of Helical Tomotherapy in Lymph Node-positive Breast Cancer Following Breast-conserving Surgery.
JO  - Anticancer research
VL  - 45
IS  - 5
SN  - 0250-7005
CY  - Kapandriti, Attiki, Greece
PB  - International Institute of Anticancer Research
M1  - DKFZ-2025-00901
SP  - 2025 - 2040
PY  - 2025
N1  - #EA:E055#
AB  - Adjuvant radiotherapy is an integral component of the interdisciplinary curative treatment of lymph node-positive breast cancer. We investigated long-term clinical outcomes of helical tomotherapy following breast-conserving surgery.This single-center analysis included 80 female patients with breast cancer stages T1-T4 and lymph node metastasis (N1-N3) who underwent breast-conserving surgery, sentinel node biopsy, and/or axillary lymph node dissection. Patients received adjuvant fractionated radiation therapy to the whole breast and regional lymph node areas using helical tomotherapy. Boost irradiation was delivered sequentially or through the simultaneous integrated boost technique. Local control (LC), metastasis, survival, toxicity, and secondary malignancy rates were retrospectively analyzed.The mean follow-up duration was 75 months. The 5- and 8-year overall survival rates were 89.4
KW  - Humans
KW  - Female
KW  - Breast Neoplasms: radiotherapy
KW  - Breast Neoplasms: pathology
KW  - Breast Neoplasms: surgery
KW  - Breast Neoplasms: mortality
KW  - Middle Aged
KW  - Mastectomy, Segmental
KW  - Adult
KW  - Aged
KW  - Lymphatic Metastasis: radiotherapy
KW  - Radiotherapy, Intensity-Modulated: methods
KW  - Radiotherapy, Intensity-Modulated: adverse effects
KW  - Radiotherapy, Adjuvant: adverse effects
KW  - Radiotherapy, Adjuvant: methods
KW  - Retrospective Studies
KW  - Treatment Outcome
KW  - Lymph Nodes: pathology
KW  - Sentinel Lymph Node Biopsy
KW  - Lymph Node Excision
KW  - Helical tomotherapy (Other)
KW  - adjuvant radiotherapy (Other)
KW  - lymph node-positive breast cancer (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40295057
DO  - DOI:10.21873/anticanres.17577
UR  - https://inrepo02.dkfz.de/record/300741
ER  -