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@ARTICLE{Peng:300742,
      author       = {Z. Peng and L. P. Siziba and H. Brenner$^*$ and D. Wernecke
                      and D. Rothenbacher and J. Genuneit},
      title        = {{C}hanges in {C}hildhood {A}topic {D}ermatitis {I}ncidence
                      and {R}isk {F}actors {O}ver {T}ime: {R}esults {F}rom {T}wo
                      {G}erman {B}irth {C}ohorts.},
      journal      = {Clinical $\&$ experimental allergy},
      volume       = {55},
      number       = {6},
      issn         = {0954-7894},
      address      = {Oxford},
      publisher    = {Blackwell Science},
      reportid     = {DKFZ-2025-00902},
      pages        = {469-480},
      year         = {2025},
      note         = {2025 Jun;55(6):469-480},
      abstract     = {Atopic dermatitis (AD) is a common allergic skin disease.
                      We aimed to assess the secular changes in the cumulative
                      incidence of childhood AD and its risk factors over a
                      decade.We used data from two methodologically similar cohort
                      studies in Ulm, Germany, the Ulm Birth Cohort Study (UBCS,
                      recruited in 2000/2001) and the Ulm SPATZ Health Study
                      (recruited in 2012/2013). The cumulative incidences of AD as
                      reported by their family physicians and parents up to the
                      age of 4 years were compared by log-rank test across the two
                      cohorts, using propensity score-based weighting to control
                      confounders. We fitted multivariable Cox regression models
                      to estimate hazard ratios and $95\%$ confidence intervals
                      (CIs) for the factors associated with the occurrence of
                      physician- and parent-reported AD and compared the results
                      between the two cohorts.The 4-year cumulative incidence
                      $(95\%$ confidence interval) of physician-reported AD
                      $(27.4\%$ $(24.4\%-30.5\%)$ in UBCS [2000/2001] vs. $26.4\%$
                      $(22.8\%-30.2\%)$ in SPATZ [2012/2013], p = 0.728) and
                      parent-reported AD $(14.5\%$ $(12.2\%-17.0\%)$ in UBCS
                      [2000/2001] vs. $16.7\%$ $(14.0\%-19.7\%)$ in SPATZ
                      [2012/2013], p = 0.211) remained stable between the two
                      cohorts after propensity score-based weighting. We observed
                      the changes in the association between AD and certain risk
                      factors (e.g., family history of AD and infantile antibiotic
                      use) over the decade, but the results need to be interpreted
                      with caution due to the limited sample size, relatively high
                      attrition rate and demographic differences between the two
                      cohorts.Over the decade, childhood AD incidence remained
                      stable. Further studies are needed to verify whether there
                      is a growing importance of environmental and
                      microbiota-related factors for AD development over time.},
      keywords     = {atopic dermatitis (Other) / cumulative incidence (Other) /
                      environment (Other) / microbiota (Other) / risk factors
                      (Other)},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40295156},
      doi          = {10.1111/cea.70066},
      url          = {https://inrepo02.dkfz.de/record/300742},
}