TY  - JOUR
AU  - Støer, Nathalie C
AU  - Botteri, Edoardo
AU  - Lindemann, Kristina
AU  - Langseth, Hilde
AU  - Turzanski-Fortner, Renée
TI  - Low-dose aspirin and non-aspirin non-steroidal anti-inflammatory drugs and epithelial ovarian cancer survival: a registry-based cohort study in Norway.
JO  - BMC cancer
VL  - 25
IS  - 1
SN  - 1471-2407
CY  - London
PB  - BioMed Central
M1  - DKFZ-2025-00905
SP  - 807
PY  - 2025
N1  - #LA:C020#
AB  - Aspirin and non-aspirin non-steroidal anti-inflammatory drugs (NA-NSAID) have been associated with improved survival in individuals with epithelial ovarian cancer (EOC); however, findings to date are inconsistent.We conducted a registry-based cohort study evaluating survival following an incident invasive EOC diagnosis including individuals diagnosed between 2004-2018 (n = 4325; n = 2206 deaths; n = 1973 EOC deaths). Evaluated exposures were low-dose aspirin and NA-NSAIDs. Two primary post-diagnosis exposure windows were evaluated: fixed post-diagnostic baseline exposure ≤ 305 days after diagnosis (use, non-use) and updated 'time-varying' exposure (never, past, current use; cumulative defined daily dose (DDD)). Pre-diagnostic exposure (use, non-use) was further evaluated. Multivariable Cox-proportional hazard models were used to estimate hazard ratios (HRs) and 95
KW  - Humans
KW  - Female
KW  - Aspirin: administration & dosage
KW  - Aspirin: therapeutic use
KW  - Anti-Inflammatory Agents, Non-Steroidal: administration & dosage
KW  - Anti-Inflammatory Agents, Non-Steroidal: therapeutic use
KW  - Carcinoma, Ovarian Epithelial: mortality
KW  - Carcinoma, Ovarian Epithelial: drug therapy
KW  - Registries: statistics & numerical data
KW  - Norway: epidemiology
KW  - Middle Aged
KW  - Aged
KW  - Ovarian Neoplasms: mortality
KW  - Ovarian Neoplasms: drug therapy
KW  - Cohort Studies
KW  - Adult
KW  - Proportional Hazards Models
KW  - Aspirin (Other)
KW  - Non-aspirin NSAIDs (Other)
KW  - Ovarian cancer (Other)
KW  - Survival (Other)
KW  - Aspirin (NLM Chemicals)
KW  - Anti-Inflammatory Agents, Non-Steroidal (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40307814
DO  - DOI:10.1186/s12885-025-14168-y
UR  - https://inrepo02.dkfz.de/record/300745
ER  -