%0 Journal Article
%A Yuan, Tanwei
%A Edelmann, Dominic
%A Moreno, Víctor
%A Georgii, Elisabeth
%A de Andrade E Sousa, Lisa Barros
%A Pelin, Helena
%A Jiang, Xiaofeng
%A Kather, Jakob Nikolas
%A Tagscherer, Katrin E
%A Roth, Wilfried
%A Bewerunge-Hudler, Melanie
%A Brobeil, Alexander
%A Kloor, Matthias
%A Bläker, Hendrik
%A Brenner, Hermann
%A Hoffmeister, Michael
%T Identification and external validation of tumor DNA methylation panel for the recurrence risk stratification of stage II colon cancer.
%J Translational oncology
%V 57
%@ 1944-7124
%C Ann Arbor, Mich.
%I [Verlag nicht ermittelbar]
%M DKFZ-2025-00907
%P 102405
%D 2025
%Z #EA:C070#LA:C070#
%X Tailoring surveillance and treatment strategies for stage II colon cancer (CC) after curative surgery remains challenging, and personalized approaches are lacking. We aimed to identify a gene methylation panel capable of stratifying high-risk stage II CC patients for recurrence beyond traditional clinical variables.Genome-wide tumor tissue DNA methylation data were analyzed from 562 stage II CC patients who underwent surgery in Germany (DACHS study). The cohort was divided into a training set (N = 395) and an internal validation set (N = 131), with external validation performed on 97 stage II CC patients from Spain. DNA methylation markers were primarily selected using the Elastic Net Cox model. The resulting prognostic index (PI), a combination of clinical factors and selected methylation markers, was compared to baseline models using clinical variables or microsatellite instability (MSI), with discrimination and prediction accuracy assessed through time-dependent receiver operating characteristic curves (AUC) and Brier scores.The final PI incorporated age, sex, tumor stage, location, and 27 DNA methylation markers. The PI consistently outperformed the baseline model including age, sex, and tumor stage in time-dependent AUC across validation cohorts (e.g., 1-year AUC and 95 
%K Colon cancer (Other)
%K DNA methylation panel (Other)
%K Prognostic index (Other)
%K Recurrence risk (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40311420
%R 10.1016/j.tranon.2025.102405
%U https://inrepo02.dkfz.de/record/300747