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@ARTICLE{Hoffmann:300750,
      author       = {G. V. Hoffmann and A. Gottschlich$^*$ and M. Subklewe$^*$
                      and S. Kobold$^*$},
      title        = {{N}ovel approaches to {CAR} {T} cell target identification
                      in acute myeloid leukemia.},
      journal      = {Current opinion in pharmacology},
      volume       = {82},
      issn         = {1471-4892},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2025-00910},
      pages        = {102524},
      year         = {2025},
      abstract     = {Identifying safe and effective CAR T cell targets in acute
                      myeloid leukemia (AML) is challenging due to the disease's
                      complexity and overlap with normal hematopoiesis. This
                      review highlights advances in target discovery for AML,
                      emphasizing innovative approaches. Structural surfaceomics
                      identifies tumor-specific protein conformations, while
                      AI-driven single-cell RNA sequencing integrates multi-source
                      data to pinpoint optimal targets. Refined cell surface
                      capture technology maps the AML surfaceome without relying
                      on predefined antibodies. These strategies enhance CAR T
                      cell specificity and minimize off-tumor effects, offering
                      promising pathways for safer and more effective AML
                      treatments and broader cancer therapies.},
      subtyp        = {Review Article},
      cin          = {MU01},
      ddc          = {340},
      cid          = {I:(DE-He78)MU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40311558},
      doi          = {10.1016/j.coph.2025.102524},
      url          = {https://inrepo02.dkfz.de/record/300750},
}