TY  - JOUR
AU  - Mandic, Marko
AU  - Safizadeh, Fatemeh
AU  - Schöttker, Ben
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Association of childhood-to-adulthood body size change with cancer risk: UK Biobank prospective cohort.
JO  - BMC medicine
VL  - 23
IS  - 1
SN  - 1741-7015
CY  - London
PB  - BioMed Central
M1  - DKFZ-2025-00935
SP  - 268
PY  - 2025
N1  - #EA:C070#LA:C070#
AB  - While excess weight in adulthood and childhood has been associated with increased cancer risk, the link between body size change from childhood to adulthood and cancer risk requires further investigation. We aimed to examine the associations of childhood-to-adulthood body size change with the risk of obesity-related cancers.We used data from the UK Biobank, a prospective population-based cohort study. The main exposure was childhood-to-adulthood body size change, constructed from self-reported body size at age 10 (categories: thinner, average, and plumper than average) and measured body mass index (BMI) at recruitment (normal weight, overweight, and obesity). Primary outcome was obesity-related cancer (13 different cancer types).Among 448,936 participants (mean [SD] age, 56.2 [8.1] years; 240,023 were female [53.5
KW  - Obesity; Overweight; Body mass index; Cancer (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40335963
DO  - DOI:10.1186/s12916-025-04052-8
UR  - https://inrepo02.dkfz.de/record/300821
ER  -