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@ARTICLE{Mandic:300821,
      author       = {M. Mandic$^*$ and F. Safizadeh$^*$ and B. Schöttker$^*$
                      and M. Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{A}ssociation of childhood-to-adulthood body size change
                      with cancer risk: {UK} {B}iobank prospective cohort.},
      journal      = {BMC medicine},
      volume       = {23},
      number       = {1},
      issn         = {1741-7015},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2025-00935},
      pages        = {268},
      year         = {2025},
      note         = {#EA:C070#LA:C070#},
      abstract     = {While excess weight in adulthood and childhood has been
                      associated with increased cancer risk, the link between body
                      size change from childhood to adulthood and cancer risk
                      requires further investigation. We aimed to examine the
                      associations of childhood-to-adulthood body size change with
                      the risk of obesity-related cancers.We used data from the UK
                      Biobank, a prospective population-based cohort study. The
                      main exposure was childhood-to-adulthood body size change,
                      constructed from self-reported body size at age 10
                      (categories: thinner, average, and plumper than average) and
                      measured body mass index (BMI) at recruitment (normal
                      weight, overweight, and obesity). Primary outcome was
                      obesity-related cancer (13 different cancer types).Among
                      448,936 participants (mean [SD] age, 56.2 [8.1] years;
                      240,023 were female $[53.5\%])$ and during a median
                      follow-up of 11.7 years (interquartile range [10.9-12.4]),
                      21,289 incident obesity-related cancer cases were recorded.
                      Most participants were either overweight $(42.6\%)$ or had
                      obesity $(24.4\%)$ at recruitment, while only a minority
                      $(16.0\%)$ reported to have been plumper than average at age
                      10. Having a larger body size in childhood was strongly
                      associated with having overweight or obesity in adulthood.
                      Compared to participants with average childhood and normal
                      adulthood body size, participants with overweight or obesity
                      in adulthood had a significantly increased risk of
                      obesity-related cancers, regardless of the childhood body
                      size (adjusted hazard ratios ranged from 1.15 $[95\%$ CI,
                      1.06-1.24] to 1.61 $[95\%$ CI, 1.50-1.73]). The strength of
                      the association was mostly determined by adulthood BMI, and
                      similar patterns were observed for colorectal, endometrial,
                      kidney, pancreatic, and esophageal cancer. However, a larger
                      body size in childhood was associated with a lower risk of
                      postmenopausal breast cancer (adjusted hazard ratio, 0.86
                      $[95\%$ CI, 0.79-0.93]).While larger body size in childhood
                      predisposes individuals to overweight and obesity in
                      adulthood, maintaining a healthy weight in adulthood may
                      help mitigate the risk of obesity-related cancers. Our
                      findings highlight the importance of preventing and reducing
                      overweight and obesity in adulthood for primary cancer
                      prevention.},
      keywords     = {Obesity; Overweight; Body mass index; Cancer (Other)},
      cin          = {C070 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40335963},
      doi          = {10.1186/s12916-025-04052-8},
      url          = {https://inrepo02.dkfz.de/record/300821},
}