%0 Journal Article
%A Foltyn-Dumitru, Martha
%A Banan, Rouzbeh
%A Schell, Marianne
%A Mahmutoglu, Mustafa Ahmed
%A Kessler, Tobias
%A Wick, Wolfgang
%A Brugnara, Gianluca
%A Bendszus, Martin
%A Sahm, Felix
%A Vollmuth, Philipp
%T Histopathological and molecular characteristics of IDH-wildtype glioblastoma without contrast enhancement: implications for clinical outcomes.
%J Neuro-Oncology
%V 27
%N 7
%@ 1522-8517
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2025-00943
%P 1878-1887
%D 2025
%Z #LA:E230# / 2025 Sep 8;27(7):1878-1887
%X Glioblastoma (GB) heterogeneity poses substantial challenges for diagnosis and treatment. IDH-wildtype GB may lack contrast enhancement on MRI and exhibit a 'low-grade radiologic appearance' (non-CE GB), a phenomenon with unclear clinical implications. This study investigates the histopathological and molecular differences and survival outcomes between contrast-enhancing (CE) and non-CE GB.This retrospective study at Heidelberg University Hospital analyzed 457 IDH-wildtype GB cases (09/2009-01/2021). Contrast enhancement on preoperative MRI was volumetrically assessed, classifying tumors as non-CE/CE GB using a 1 cm³ cut-off. Molecular and histopathological features, including microvascular proliferation, necrosis, and overall survival (OS), were compared between the groups.Of the initial cohort, 352 (77
%K IDH-wildtype glioblastoma (Other)
%K MRI (Other)
%K contrast-enhancement (Other)
%K histopathology (Other)
%K low-grade radiologic appearance (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40108725
%R 10.1093/neuonc/noaf070
%U https://inrepo02.dkfz.de/record/300832