TY  - JOUR
AU  - Foltyn-Dumitru, Martha
AU  - Banan, Rouzbeh
AU  - Schell, Marianne
AU  - Mahmutoglu, Mustafa Ahmed
AU  - Kessler, Tobias
AU  - Wick, Wolfgang
AU  - Brugnara, Gianluca
AU  - Bendszus, Martin
AU  - Sahm, Felix
AU  - Vollmuth, Philipp
TI  - Histopathological and molecular characteristics of IDH-wildtype glioblastoma without contrast enhancement: implications for clinical outcomes.
JO  - Neuro-Oncology
VL  - 27
IS  - 7
SN  - 1522-8517
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2025-00943
SP  - 1878-1887
PY  - 2025
N1  - #LA:E230# / 2025 Sep 8;27(7):1878-1887
AB  - Glioblastoma (GB) heterogeneity poses substantial challenges for diagnosis and treatment. IDH-wildtype GB may lack contrast enhancement on MRI and exhibit a 'low-grade radiologic appearance' (non-CE GB), a phenomenon with unclear clinical implications. This study investigates the histopathological and molecular differences and survival outcomes between contrast-enhancing (CE) and non-CE GB.This retrospective study at Heidelberg University Hospital analyzed 457 IDH-wildtype GB cases (09/2009-01/2021). Contrast enhancement on preoperative MRI was volumetrically assessed, classifying tumors as non-CE/CE GB using a 1 cm³ cut-off. Molecular and histopathological features, including microvascular proliferation, necrosis, and overall survival (OS), were compared between the groups.Of the initial cohort, 352 (77
KW  - IDH-wildtype glioblastoma (Other)
KW  - MRI (Other)
KW  - contrast-enhancement (Other)
KW  - histopathology (Other)
KW  - low-grade radiologic appearance (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40108725
DO  - DOI:10.1093/neuonc/noaf070
UR  - https://inrepo02.dkfz.de/record/300832
ER  -