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@ARTICLE{Iliaskou:301265,
      author       = {C. Iliaskou$^*$ and M. Gainey$^*$ and B. Thomann$^*$ and M.
                      Kollefrath$^*$ and R. Saum$^*$ and E. Gkika$^*$ and U. A.
                      Wittel and D. A. Ruess and A.-L. Grosu$^*$ and D.
                      Baltas$^*$},
      title        = {{D}evelopment of a {TLD}-100 based set up for in vivo
                      dosimetry in {I}ntraoperative {E}lectron {B}eam {R}adiation
                      {T}herapy ({IOERT}): an experimental and clinical
                      evaluation.},
      journal      = {Zeitschrift für medizinische Physik},
      volume       = {nn},
      issn         = {0939-3889},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2025-00950},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {This study presents an in-house developed set-up enabling
                      the placement of multiple TLDs over the target region, for
                      in vivo dosimetry in intraoperative electron beam
                      radiotherapy (IOERT).TLD-100 (LiF:MgTi) rods were calibrated
                      at 10 Gy and their response was determined for the nominal
                      electron energies of the Mobetron LINAC within the dose
                      range from 4 Gy to 20 Gy. Irradiation of various set-ups was
                      performed using the ionisation chambers (IC) ROOS parallel
                      plate 34001 (PTW, Freiburg) and 3D Semiflex 31021 (PTW,
                      Freiburg), a microdiamond detector 60019 (PTW, Freiburg) and
                      EBT3 films (Ashland™) to investigate beam perturbations
                      that may result due to the structure of the set up. EGSnrc
                      Monte Carlo (MC) simulations evaluated the response of the
                      TLDs in clinical beams of the available electron energies,
                      the influence of the catheter to the TLD dose scoring and
                      the depth dependence of the TLD dose assessment. TLD
                      measurements in-phantoms and in patient in vivo were
                      realised and compared to the expected doses estimated using
                      data of water phantom measurements and 3D MC electron dose
                      calculations of a dedicated IOERT treatment planning system
                      (Radiance TPS- GmV, Tres Cantos, Madrid).MC and measurements
                      verified that no energy correction is needed for the used
                      electron beams. Correction factors for the dose non-linear
                      response were evaluated. High resolution dose measurements
                      showed local hot spots beneath the flap. However, there are
                      no significant perturbations of the electron beam or on the
                      dose delivery to the targeted volume. MC simulations
                      demonstrated no signal attenuation due to the catheter and 1
                      $\%$ effect of the depth of TLD measurement relative to the
                      depth of calibration was noted. TLD measurements in phantom
                      set-ups agreed with expected doses with less than 2.6 $\%$
                      in phantoms and by 1 $\%$ in patient in vivo.Our results
                      demonstrate the suitability of using the implemented
                      TLD-based workflow for in vivo dosimetry purposes in the
                      operation room (OR) environment.},
      keywords     = {IOERT (Other) / TLD-100 dosimetry (Other) / in vivo
                      dosimetry (Other)},
      cin          = {FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40345917},
      doi          = {10.1016/j.zemedi.2025.04.007},
      url          = {https://inrepo02.dkfz.de/record/301265},
}