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000301271 1001_ $$00000-0001-8579-1435$$aByun, Jinyoung$$b0
000301271 245__ $$aGenome-wide association study for lung cancer in 6531 African Americans reveals new susceptibility loci.
000301271 260__ $$aOxford$$bOxford Univ. Press$$c2025
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000301271 500__ $$aVolume 34, Issue 14, 15 July 2025, Pages 1227–1237
000301271 520__ $$aDespite lung cancer affecting all races and ethnicities, disparities are observed in incidence and mortality rates among different ethnic groups in the United States. Non-Hispanic African Americans had a high incidence rate of lung cancer at 55.8 per 100 000 people, as well as the highest death rate at 37.2 per 100 000 people from 2016 to 2020. While previous genome-wide association studies (GWAS) have identified over 45 susceptibility risk loci that influence lung cancer development, few GWAS have investigated the etiology of lung cancer in African Americans. To address this gap in knowledge, we conducted GWAS of lung cancer focused on studying African Americans, comprising 2267 lung cancer cases and 4264 controls. We identified three loci associated with lung cancer, one with lung adenocarcinoma, and four with lung squamous cell carcinoma in this population at the genomic-wide significance level. Among them, three novel loci were identified near VWF at 12p13.31 for overall lung cancer and GACAT3 at 2p24.3 and LMAN1L at 15q24.1 for lung squamous cell carcinoma. In addition, we confirmed previously reported risk loci with known or new lead variants near CHRNA5 at 15q25.1 and CYP2A6 at 19q13.2 associated with lung cancer and TRIP13 at 5p15.33 and ERC1 at 12p13.33 associated with lung squamous cell carcinoma. Further multi-step functional analyses shed light on biological mechanisms underlying these associations of lung cancer in this population. Our study highlights the importance of ancestry-specific studies for the potential alleviation of lung cancer burden in African Americans.
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000301271 650_7 $$2Other$$aAfrican American
000301271 650_7 $$2Other$$aGenome-wide association study
000301271 650_7 $$2Other$$aLung cancer
000301271 650_7 $$2Other$$aPolygenic risk score
000301271 650_7 $$2Other$$aPost-GWAS
000301271 7001_ $$aHan, Younghun$$b1
000301271 7001_ $$00000-0002-0955-2384$$aChoi, Jiyeon$$b2
000301271 7001_ $$00000-0003-1176-1561$$aSun, Ryan$$b3
000301271 7001_ $$00000-0002-1172-5686$$aShaw, Vikram R$$b4
000301271 7001_ $$00000-0002-4939-515X$$aZhu, Catherine$$b5
000301271 7001_ $$aXiao, Xiangjun$$b6
000301271 7001_ $$aLusk, Christine$$b7
000301271 7001_ $$00000-0002-4549-9111$$aBadr, Hoda$$b8
000301271 7001_ $$aLee, Hyun-Sung$$b9
000301271 7001_ $$aJang, Hee-Jin$$b10
000301271 7001_ $$00000-0002-1333-1752$$aLi, Yafang$$b11
000301271 7001_ $$aLim, Hyeyeun$$b12
000301271 7001_ $$aLong, Erping$$b13
000301271 7001_ $$aLiu, Yanhong$$b14
000301271 7001_ $$aKachuri, Linda$$b15
000301271 7001_ $$aWalsh, Kyle M$$b16
000301271 7001_ $$aWiencke, John K$$b17
000301271 7001_ $$aAlbanes, Demetrius$$b18
000301271 7001_ $$aLam, Stephen$$b19
000301271 7001_ $$aTardon, Adonina$$b20
000301271 7001_ $$aNeuhouser, Marian L$$b21
000301271 7001_ $$aBarnett, Matt J$$b22
000301271 7001_ $$aChen, Chu$$b23
000301271 7001_ $$aBojesen, Stig$$b24
000301271 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b25$$udkfz
000301271 7001_ $$aLandi, Maria Teresa$$b26
000301271 7001_ $$aJohansson, Mattias$$b27
000301271 7001_ $$0P:(DE-He78)4981f4ef151aea881f38b33df8e35a21$$aRisch, Angela$$b28
000301271 7001_ $$aWichmann, H-Erich$$b29
000301271 7001_ $$aBickeböller, Heike$$b30
000301271 7001_ $$aChristiani, David C$$b31
000301271 7001_ $$aRennert, Gad$$b32
000301271 7001_ $$aArnold, Susanne$$b33
000301271 7001_ $$aField, John K$$b34
000301271 7001_ $$00000-0001-7622-376X$$aShete, Sanjay$$b35
000301271 7001_ $$aLe Marchand, Loic$$b36
000301271 7001_ $$00000-0002-2603-7296$$aLiu, Geoffrey$$b37
000301271 7001_ $$aAndrew, Angeline S$$b38
000301271 7001_ $$aZienolddiny, Shanbeh$$b39
000301271 7001_ $$aGrankvist, Kjell$$b40
000301271 7001_ $$aJohansson, Mikael$$b41
000301271 7001_ $$aCaporaso, Neil$$b42
000301271 7001_ $$aTaylor, Fiona$$b43
000301271 7001_ $$aLazarus, Philip$$b44
000301271 7001_ $$00000-0003-3241-3216$$aSchabath, Matthew B$$b45
000301271 7001_ $$00000-0003-3833-8448$$aAldrich, Melinda C$$b46
000301271 7001_ $$aPatel, Alpa$$b47
000301271 7001_ $$00000-0001-7067-7752$$aLin, Xihong$$b48
000301271 7001_ $$aZanetti, Krista A$$b49
000301271 7001_ $$aHarris, Curtis C$$b50
000301271 7001_ $$aChanock, Stephen$$b51
000301271 7001_ $$aMcKay, James$$b52
000301271 7001_ $$00000-0002-9525-1157$$aSchwartz, Ann G$$b53
000301271 7001_ $$aHung, Rayjean J$$b54
000301271 7001_ $$aAmos, Christopher I$$b55
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