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@ARTICLE{Byun:301271,
      author       = {J. Byun and Y. Han and J. Choi and R. Sun and V. R. Shaw
                      and C. Zhu and X. Xiao and C. Lusk and H. Badr and H.-S. Lee
                      and H.-J. Jang and Y. Li and H. Lim and E. Long and Y. Liu
                      and L. Kachuri and K. M. Walsh and J. K. Wiencke and D.
                      Albanes and S. Lam and A. Tardon and M. L. Neuhouser and M.
                      J. Barnett and C. Chen and S. Bojesen and H. Brenner$^*$ and
                      M. T. Landi and M. Johansson and A. Risch$^*$ and H.-E.
                      Wichmann and H. Bickeböller and D. C. Christiani and G.
                      Rennert and S. Arnold and J. K. Field and S. Shete and L. Le
                      Marchand and G. Liu and A. S. Andrew and S. Zienolddiny and
                      K. Grankvist and M. Johansson and N. Caporaso and F. Taylor
                      and P. Lazarus and M. B. Schabath and M. C. Aldrich and A.
                      Patel and X. Lin and K. A. Zanetti and C. C. Harris and S.
                      Chanock and J. McKay and A. G. Schwartz and R. J. Hung and
                      C. I. Amos},
      collaboration = {I.-I. Consortium},
      title        = {{G}enome-wide association study for lung cancer in 6531
                      {A}frican {A}mericans reveals new susceptibility loci.},
      journal      = {Human molecular genetics},
      volume       = {34},
      number       = {14},
      issn         = {0964-6906},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2025-00956},
      pages        = {1227–1237},
      year         = {2025},
      note         = {Volume 34, Issue 14, 15 July 2025, Pages 1227–1237},
      abstract     = {Despite lung cancer affecting all races and ethnicities,
                      disparities are observed in incidence and mortality rates
                      among different ethnic groups in the United States.
                      Non-Hispanic African Americans had a high incidence rate of
                      lung cancer at 55.8 per 100 000 people, as well as the
                      highest death rate at 37.2 per 100 000 people from 2016 to
                      2020. While previous genome-wide association studies (GWAS)
                      have identified over 45 susceptibility risk loci that
                      influence lung cancer development, few GWAS have
                      investigated the etiology of lung cancer in African
                      Americans. To address this gap in knowledge, we conducted
                      GWAS of lung cancer focused on studying African Americans,
                      comprising 2267 lung cancer cases and 4264 controls. We
                      identified three loci associated with lung cancer, one with
                      lung adenocarcinoma, and four with lung squamous cell
                      carcinoma in this population at the genomic-wide
                      significance level. Among them, three novel loci were
                      identified near VWF at 12p13.31 for overall lung cancer and
                      GACAT3 at 2p24.3 and LMAN1L at 15q24.1 for lung squamous
                      cell carcinoma. In addition, we confirmed previously
                      reported risk loci with known or new lead variants near
                      CHRNA5 at 15q25.1 and CYP2A6 at 19q13.2 associated with lung
                      cancer and TRIP13 at 5p15.33 and ERC1 at 12p13.33 associated
                      with lung squamous cell carcinoma. Further multi-step
                      functional analyses shed light on biological mechanisms
                      underlying these associations of lung cancer in this
                      population. Our study highlights the importance of
                      ancestry-specific studies for the potential alleviation of
                      lung cancer burden in African Americans.},
      keywords     = {African American (Other) / Genome-wide association study
                      (Other) / Lung cancer (Other) / Polygenic risk score (Other)
                      / Post-GWAS (Other)},
      cin          = {C070 / C120 / HD01 / B370},
      ddc          = {570},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)B370-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40341939},
      doi          = {10.1093/hmg/ddaf059},
      url          = {https://inrepo02.dkfz.de/record/301271},
}