TY  - JOUR
AU  - Heumann, Philipp
AU  - Benner, Axel
AU  - Behrens, Sabine
AU  - Chang-Claude, Jenny
AU  - Seibold, Petra
TI  - Prognostic value of cancer-related fatigue at the end of radiotherapy for overall survival ≥ 10 years in women with breast cancer.
JO  - Breast cancer research
VL  - 27
IS  - 1
SN  - 1465-5411
CY  - London
PB  - BioMed Central
M1  - DKFZ-2025-00976
SP  - 76
PY  - 2025
N1  - #EA:C020#LA:C020#
AB  - Cancer-related fatigue (CRF) is a common symptom in breast cancer patients and survivors, which can substantially impair quality of life. Previous studies suggested that CRF may be associated with poorer survival outcomes, but had limited follow-up duration or insufficient adjustment for established prognostic factors. The aim of this analysis was to assess the prognostic value of CRF at the end of radiotherapy for overall survival in a cohort of women with breast cancer with a median follow-up time of 19 years.Data from the prospective ISE study, which enrolled women with non-metastatic breast cancer between 1998 and 2001, were analysed. Patients did not receive chemotherapy. A vital status follow-up was conducted in 2019. CRF was collected at the end of radiotherapy using the EORTC QLQ-C30 and classified using the threshold of clinical importance. Cox regression models adjusted for CRF, age, body mass index (BMI), tumour size, nodal involvement, grading and receptor status were calculated.Of 437 patients with fatigue assessments, 164 (38
KW  - Breast neoplasms (Other)
KW  - Fatigue (Other)
KW  - Patient reported outcome measures (Other)
KW  - Radiotherapy (Other)
KW  - Survival (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40355939
DO  - DOI:10.1186/s13058-025-02036-3
UR  - https://inrepo02.dkfz.de/record/301292
ER  -