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@ARTICLE{Cicala:301317,
      author       = {C. M. Cicala and S. Bauer$^*$ and M. C. Heinrich and C.
                      Serrano},
      title        = {{G}astrointestinal {S}tromal {T}umor: {C}urrent
                      {A}pproaches and {F}uture {D}irections in the {T}reatment of
                      {A}dvanced {D}isease.},
      journal      = {Hematology, oncology clinics of North America},
      volume       = {39},
      number       = {4},
      issn         = {0889-8588},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2025-00989},
      pages        = {773-784},
      year         = {2025},
      note         = {Volume 39, Issue 4, August 2025, Pages 773-784},
      abstract     = {This review discusses the current and future landscape of
                      advanced gastrointestinal stromal tumor (GIST) treatment. It
                      covers the role of tyrosine kinase inhibitors (TKIs),
                      specifically imatinib, and further treatment options, such
                      as sunitinib, regorafenib, and ripretinib, as well as
                      avapritinib for platelet-derived growth factor receptor
                      alpha D842V mutations. In addition, this review emphasizes
                      individualized treatment strategies within multidisciplinary
                      expert teams, including surgery and other locoregional
                      therapies, together with the importance of mutation-guided
                      approaches, particularly for wild-type GISTs. Finally, it
                      explores the potential of next-generation KIT inhibitors,
                      combination therapies, and other investigational
                      approaches.},
      subtyp        = {Review Article},
      keywords     = {Gastrointestinal stromal tumor (GIST) (Other) / Imatinib
                      (Other) / KIT mutation (Other) / PDGFRA mutation (Other) /
                      Targeted therapy (Other) / Tyrosine-kinase inhibitors (TKIs)
                      (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40368739},
      doi          = {10.1016/j.hoc.2025.04.006},
      url          = {https://inrepo02.dkfz.de/record/301317},
}