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000301319 0247_ $$2doi$$a10.3390/ijms26093976
000301319 0247_ $$2pmid$$apmid:40362215
000301319 0247_ $$2ISSN$$a1422-0067
000301319 0247_ $$2ISSN$$a1661-6596
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000301319 041__ $$aEnglish
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000301319 1001_ $$aGunasekara, Nadira$$b0
000301319 245__ $$aThe Influence of an Acute Endurance Intervention on Breast Cancer Cell Growth-A Pilot Study.
000301319 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2025
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000301319 520__ $$aExercise potentially inhibits tumor growth. It remains unclear which processes mediate these effects. Alterations of cytokine concentration in serum can influence cancer cell growth and may cause cell growth inhibition. This pilot study examines whether exercise-induced conditioning in serum can directly affect tumor cells. It focuses on serum collected before and after acute endurance exercise and its impact in vitro. Participants underwent a 1 h endurance training on a cycle ergometer. Samples were collected before, after, and two hours post-exercise. MDA-MB-231 cells were incubated with serum, and cell vitality and proliferation were assessed. Cytokine arrays identified relevant cytokine concentration changes. After identifying CXCL9 as a possible contributor to inhibitory effects, we inhibited the CXCR3 pathway and reassessed vitality. Exercise-conditioned serum significantly reduced cell vitality and proliferation post-intervention and after resting. Cytokine arrays revealed changes in multiple concentrations, and the inhibition of CXCL9 resulted in growth inhibitory effects. Our findings suggest that serum conditioned by an endurance intervention causes changes in cancer cell growth. Based on our observations, the alterations in serum cause growth-inhibitory effects, possibly mediated through the CXCR3 axis. This study provides preliminary evidence supporting the role of exercise in modulating the cancer cell growth directly by changes in serum.
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000301319 650_7 $$2Other$$aexercise oncology
000301319 650_7 $$2Other$$amyokines
000301319 650_7 $$2Other$$asports medicine
000301319 650_7 $$2NLM Chemicals$$aReceptors, CXCR3
000301319 650_7 $$2NLM Chemicals$$aChemokine CXCL9
000301319 650_7 $$2NLM Chemicals$$aCytokines
000301319 650_7 $$2NLM Chemicals$$aCXCR3 protein, human
000301319 650_7 $$2NLM Chemicals$$aCXCL9 protein, human
000301319 650_2 $$2MeSH$$aHumans
000301319 650_2 $$2MeSH$$aPilot Projects
000301319 650_2 $$2MeSH$$aBreast Neoplasms: pathology
000301319 650_2 $$2MeSH$$aBreast Neoplasms: metabolism
000301319 650_2 $$2MeSH$$aBreast Neoplasms: blood
000301319 650_2 $$2MeSH$$aFemale
000301319 650_2 $$2MeSH$$aCell Proliferation
000301319 650_2 $$2MeSH$$aCell Line, Tumor
000301319 650_2 $$2MeSH$$aReceptors, CXCR3: metabolism
000301319 650_2 $$2MeSH$$aChemokine CXCL9: blood
000301319 650_2 $$2MeSH$$aChemokine CXCL9: metabolism
000301319 650_2 $$2MeSH$$aCytokines: blood
000301319 650_2 $$2MeSH$$aCytokines: metabolism
000301319 650_2 $$2MeSH$$aExercise: physiology
000301319 650_2 $$2MeSH$$aAdult
000301319 650_2 $$2MeSH$$aMiddle Aged
000301319 650_2 $$2MeSH$$aPhysical Endurance
000301319 650_2 $$2MeSH$$aCell Survival
000301319 650_2 $$2MeSH$$aEndurance Training
000301319 7001_ $$0P:(DE-He78)f52b77d7ab843c9b900134aafc61638a$$aClauss, Dorothea$$b1$$udkfz
000301319 7001_ $$aVoss, Anika$$b2
000301319 7001_ $$00009-0008-2284-1237$$aSchurz, Konstantin$$b3
000301319 7001_ $$aFleck, Katharina$$b4
000301319 7001_ $$aNeu-Gil, Pablo$$b5
000301319 7001_ $$aBloch, Wilhelm$$b6
000301319 773__ $$0PERI:(DE-600)2019364-6$$a10.3390/ijms26093976$$gVol. 26, no. 9, p. 3976 -$$n9$$p3976$$tInternational journal of molecular sciences$$v26$$x1422-0067$$y2025
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