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@ARTICLE{Gunasekara:301319,
      author       = {N. Gunasekara and D. Clauss$^*$ and A. Voss and K. Schurz
                      and K. Fleck and P. Neu-Gil and W. Bloch},
      title        = {{T}he {I}nfluence of an {A}cute {E}ndurance {I}ntervention
                      on {B}reast {C}ancer {C}ell {G}rowth-{A} {P}ilot {S}tudy.},
      journal      = {International journal of molecular sciences},
      volume       = {26},
      number       = {9},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DKFZ-2025-00991},
      pages        = {3976},
      year         = {2025},
      abstract     = {Exercise potentially inhibits tumor growth. It remains
                      unclear which processes mediate these effects. Alterations
                      of cytokine concentration in serum can influence cancer cell
                      growth and may cause cell growth inhibition. This pilot
                      study examines whether exercise-induced conditioning in
                      serum can directly affect tumor cells. It focuses on serum
                      collected before and after acute endurance exercise and its
                      impact in vitro. Participants underwent a 1 h endurance
                      training on a cycle ergometer. Samples were collected
                      before, after, and two hours post-exercise. MDA-MB-231 cells
                      were incubated with serum, and cell vitality and
                      proliferation were assessed. Cytokine arrays identified
                      relevant cytokine concentration changes. After identifying
                      CXCL9 as a possible contributor to inhibitory effects, we
                      inhibited the CXCR3 pathway and reassessed vitality.
                      Exercise-conditioned serum significantly reduced cell
                      vitality and proliferation post-intervention and after
                      resting. Cytokine arrays revealed changes in multiple
                      concentrations, and the inhibition of CXCL9 resulted in
                      growth inhibitory effects. Our findings suggest that serum
                      conditioned by an endurance intervention causes changes in
                      cancer cell growth. Based on our observations, the
                      alterations in serum cause growth-inhibitory effects,
                      possibly mediated through the CXCR3 axis. This study
                      provides preliminary evidence supporting the role of
                      exercise in modulating the cancer cell growth directly by
                      changes in serum.},
      keywords     = {Humans / Pilot Projects / Breast Neoplasms: pathology /
                      Breast Neoplasms: metabolism / Breast Neoplasms: blood /
                      Female / Cell Proliferation / Cell Line, Tumor / Receptors,
                      CXCR3: metabolism / Chemokine CXCL9: blood / Chemokine
                      CXCL9: metabolism / Cytokines: blood / Cytokines: metabolism
                      / Exercise: physiology / Adult / Middle Aged / Physical
                      Endurance / Cell Survival / Endurance Training / exercise
                      oncology (Other) / myokines (Other) / sports medicine
                      (Other) / Receptors, CXCR3 (NLM Chemicals) / Chemokine CXCL9
                      (NLM Chemicals) / Cytokines (NLM Chemicals) / CXCR3 protein,
                      human (NLM Chemicals) / CXCL9 protein, human (NLM
                      Chemicals)},
      cin          = {C110},
      ddc          = {540},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40362215},
      doi          = {10.3390/ijms26093976},
      url          = {https://inrepo02.dkfz.de/record/301319},
}