TY  - JOUR
AU  - Hoegen-Saßmannshausen, Philipp
AU  - Hartschuh, Tobias P
AU  - Renkamp, Claudia Katharina
AU  - Buchele, Carolin
AU  - Schlüter, Fabian
AU  - Sandrini, Elisabetta
AU  - Weykamp, Fabian
AU  - Regnery, Sebastian
AU  - Meixner, Eva
AU  - König, Laila
AU  - Debus, Jürgen
AU  - Klüter, Sebastian
AU  - Hörner-Rieber, Juliane
TI  - Intrafractional Motion in Online-Adaptive Magnetic Resonance-Guided Radiotherapy of Adrenal Metastases Leads to Reduced Target Volume Coverage and Elevated Organ-at-Risk Doses.
JO  - Cancers
VL  - 17
IS  - 9
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2025-00992
SP  - 1533
PY  - 2025
N1  - #EA:E050#LA:E050#
AB  - Stereotactic body radiotherapy is frequently used in patients with adrenal metastases. Motion of adherent radiosensitive organs at risk (OARs) and tumors influence OAR toxicity and tumor control. Online-adaptive Magnetic Resonance-guided radiotherapy (MRgRT) can address and mitigate interfractional changes. However, the impact of intrafractional variations in adrenal MRgRT is unknown.A total of 23 patients with 24 adrenal metastases were treated with MRgRT. After daily plan adaptation and before beam application, an additional (preRT) 3d MRI was acquired. PreRT target volumes and OARs were retrospectively recontoured in 200 fractions. The delivered, online-adapted treatment plans, as well as non-adapted baseline plans, were calculated on these re-contoured structures to quantify the dosimetric impact of intrafractional variations on target volume coverage and OAR doses with and without online adaptation. Normal tissue complication probabilities (NTCPs) were calculated.The median time between the two MRIs was 56.4 min. GTV and PTV coverage (dose to 95
KW  - MR-linac (Other)
KW  - SABR (Other)
KW  - SBRT (Other)
KW  - drift (Other)
KW  - gating (Other)
KW  - intrafractional changes (Other)
KW  - oligometastasis (Other)
KW  - peristalsis (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40361458
DO  - DOI:10.3390/cancers17091533
UR  - https://inrepo02.dkfz.de/record/301320
ER  -