%0 Journal Article
%A Ozair, M Zeeshan
%A Halmos, Balazs
%A D'Aiello, Angelica
%A Yun, Jaewon
%A Filippi, Andrea R
%A Rimner, Andreas
%A Lin, Steven H
%A Simone, Charles B
%A Ohri, Nitin
%T Chemotherapy-Free Treatment with Radiotherapy and Immunotherapy for Locally Advanced Non-Small Cell Lung Cancer.
%J Cancers
%V 17
%N 9
%@ 2072-6694
%C Basel
%I MDPI
%M DKFZ-2025-00993
%P 1524
%D 2025
%X Background: Concurrent chemoradiotherapy (CRT) followed by immunotherapy is a standard treatment for locally advanced non-small cell lung cancer (LA-NSCLC), yet many patients are ineligible due to treatment-related toxicity or poor functional status. Chemotherapy-free approaches using radiotherapy (RT) and immunotherapy may offer a safer and equally effective alternative in select patient populations. Methods: A comprehensive literature review was conducted using PubMed, Google Scholar, and relevant conference proceedings focusing on trials between 2000 and 2024. Studies investigating chemotherapy-free regimens combining RT and immunotherapy in LA-NSCLC were analyzed, with emphasis on clinical outcomes, biomarker use, treatment sequencing, radiation dose/fractionation, and safety. Results: Multiple Phase I/II trials reported promising efficacy with one-year progression-free survival (PFS) ranging from 39
%K LA-NSCLC (Other)
%K chemotherapy-free (Other)
%K immunotherapy (Other)
%K radiation therapy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40361451
%R 10.3390/cancers17091524
%U https://inrepo02.dkfz.de/record/301321