TY  - JOUR
AU  - Ozair, M Zeeshan
AU  - Halmos, Balazs
AU  - D'Aiello, Angelica
AU  - Yun, Jaewon
AU  - Filippi, Andrea R
AU  - Rimner, Andreas
AU  - Lin, Steven H
AU  - Simone, Charles B
AU  - Ohri, Nitin
TI  - Chemotherapy-Free Treatment with Radiotherapy and Immunotherapy for Locally Advanced Non-Small Cell Lung Cancer.
JO  - Cancers
VL  - 17
IS  - 9
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2025-00993
SP  - 1524
PY  - 2025
AB  - Background: Concurrent chemoradiotherapy (CRT) followed by immunotherapy is a standard treatment for locally advanced non-small cell lung cancer (LA-NSCLC), yet many patients are ineligible due to treatment-related toxicity or poor functional status. Chemotherapy-free approaches using radiotherapy (RT) and immunotherapy may offer a safer and equally effective alternative in select patient populations. Methods: A comprehensive literature review was conducted using PubMed, Google Scholar, and relevant conference proceedings focusing on trials between 2000 and 2024. Studies investigating chemotherapy-free regimens combining RT and immunotherapy in LA-NSCLC were analyzed, with emphasis on clinical outcomes, biomarker use, treatment sequencing, radiation dose/fractionation, and safety. Results: Multiple Phase I/II trials reported promising efficacy with one-year progression-free survival (PFS) ranging from 39
KW  - LA-NSCLC (Other)
KW  - chemotherapy-free (Other)
KW  - immunotherapy (Other)
KW  - radiation therapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40361451
DO  - DOI:10.3390/cancers17091524
UR  - https://inrepo02.dkfz.de/record/301321
ER  -