%0 Journal Article
%A Seum, Teresa
%A Cardoso, Rafael
%A Stevenson-Hoare, Joshua
%A Holleczek, Bernd
%A Schöttker, Ben
%A Hoffmeister, Michael
%A Brenner, Hermann
%T Exploring metabolomics for colorectal cancer risk prediction: evidence from the UK Biobank and ESTHER cohorts.
%J BMC medicine
%V 23
%N 1
%@ 1741-7015
%C London
%I BioMed Central
%M DKFZ-2025-00995
%P 283
%D 2025
%Z #EA:C070#LA:C070#
%X While metabolic pathway alterations are linked to colorectal cancer (CRC), the predictive value of pre-diagnostic metabolomic profiling in CRC risk assessment remains to be clarified. This study evaluated the predictive performance of a metabolomics risk panel (MRP) both independently and in combination with established risk factors.We derived, internally validated (IV), and externally validated (EV) a metabolomics risk panel (MRP) for CRC from data of the UK Biobank (UKB) and the German ESTHER cohort. Baseline blood samples were assessed for 249 metabolites using nuclear magnetic resonance spectroscopy analysis. We applied LASSO Cox proportional hazards regression to identify metabolites for inclusion in the MRP and evaluated the model performance using the concordance index (C-index). We compared the performance of the MRP to an environmental risk panel (ERP; sex, age, body mass index, smoking status, and alcohol consumption) and a genetic risk panel (GRP; polygenic risk score).The study included 154,892 participants of the UKB cohort (mean age at baseline 54.5 years; 55.5
%K Humans
%K Colorectal Neoplasms: metabolism
%K Colorectal Neoplasms: epidemiology
%K Colorectal Neoplasms: diagnosis
%K Colorectal Neoplasms: genetics
%K Male
%K Female
%K Middle Aged
%K Metabolomics: methods
%K United Kingdom: epidemiology
%K Risk Assessment: methods
%K Biological Specimen Banks
%K Aged
%K Risk Factors
%K Cohort Studies
%K UK Biobank
%K Biomarkers (Other)
%K Colorectal cancer (Other)
%K Metabolomics (Other)
%K Risk stratification (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40361100
%R 10.1186/s12916-025-04107-w
%U https://inrepo02.dkfz.de/record/301323