TY  - JOUR
AU  - Seum, Teresa
AU  - Cardoso, Rafael
AU  - Stevenson-Hoare, Joshua
AU  - Holleczek, Bernd
AU  - Schöttker, Ben
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Exploring metabolomics for colorectal cancer risk prediction: evidence from the UK Biobank and ESTHER cohorts.
JO  - BMC medicine
VL  - 23
IS  - 1
SN  - 1741-7015
CY  - London
PB  - BioMed Central
M1  - DKFZ-2025-00995
SP  - 283
PY  - 2025
N1  - #EA:C070#LA:C070#
AB  - While metabolic pathway alterations are linked to colorectal cancer (CRC), the predictive value of pre-diagnostic metabolomic profiling in CRC risk assessment remains to be clarified. This study evaluated the predictive performance of a metabolomics risk panel (MRP) both independently and in combination with established risk factors.We derived, internally validated (IV), and externally validated (EV) a metabolomics risk panel (MRP) for CRC from data of the UK Biobank (UKB) and the German ESTHER cohort. Baseline blood samples were assessed for 249 metabolites using nuclear magnetic resonance spectroscopy analysis. We applied LASSO Cox proportional hazards regression to identify metabolites for inclusion in the MRP and evaluated the model performance using the concordance index (C-index). We compared the performance of the MRP to an environmental risk panel (ERP; sex, age, body mass index, smoking status, and alcohol consumption) and a genetic risk panel (GRP; polygenic risk score).The study included 154,892 participants of the UKB cohort (mean age at baseline 54.5 years; 55.5
KW  - Humans
KW  - Colorectal Neoplasms: metabolism
KW  - Colorectal Neoplasms: epidemiology
KW  - Colorectal Neoplasms: diagnosis
KW  - Colorectal Neoplasms: genetics
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - Metabolomics: methods
KW  - United Kingdom: epidemiology
KW  - Risk Assessment: methods
KW  - Biological Specimen Banks
KW  - Aged
KW  - Risk Factors
KW  - Cohort Studies
KW  - UK Biobank
KW  - Biomarkers (Other)
KW  - Colorectal cancer (Other)
KW  - Metabolomics (Other)
KW  - Risk stratification (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40361100
DO  - DOI:10.1186/s12916-025-04107-w
UR  - https://inrepo02.dkfz.de/record/301323
ER  -