% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Eichenauer:301324,
      author       = {D. A. Eichenauer and A. Basaran and I. Bühnen and M. Fuchs
                      and B. von Tresckow$^*$ and A. Rosenwald and M.-L. Hansmann
                      and H.-W. Bernd and P. Borchmann and W. Klapper and S.
                      Hartmann},
      title        = {{R}efining histopathological growth pattern-based risk
                      group discrimination in nodular lymphocyte-predominant
                      {H}odgkin lymphoma: an analysis from the {G}erman {H}odgkin
                      {S}tudy {G}roup.},
      journal      = {Leukemia},
      volume       = {39},
      number       = {7},
      issn         = {0887-6924},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2025-00996},
      pages        = {1735-1743},
      year         = {2025},
      note         = {2025 Jul;39(7):1735-1743},
      abstract     = {Histopathological growth patterns (GP) in nodular
                      lymphocyte-predominant Hodgkin lymphoma (NLPHL) have
                      previously been divided into GP AB (typical) vs CDEF
                      (variant). However, it is unclear whether this division is
                      optimal. We thus investigated alternative GP grouping
                      approaches (GP ABC vs DEF; GP ABCF vs DE). Overall, 583
                      NLPHL patients who had first-line treatment within GHSG
                      trials were included in the analysis. Median age was 39
                      years; $74\%$ of patients were male; $76\%$ presented with
                      early-stage and $24\%$ with advanced-stage disease. The
                      5-year and 10-year progression-free survival (PFS) estimates
                      for all patients were $85.9\%$ and $76.6\%;$ overall
                      survival (OS) estimates were $95.8\%$ and $94.5\%.$
                      Significant PFS and OS differences were detected for the
                      comparison GP ABCF vs DE with worse outcomes for the GP DE
                      group (HR: 1.7; $95\%-CI:$ 1.1-2.7; HR: 2.5; $95\%-CI:$
                      1.1-5.7). No PFS and OS differences were observed for the
                      comparisons GP AB vs CDEF and GP ABC vs DEF. Median time to
                      death was shorter and death more often due to NLPHL in the
                      GP DE (13 months; $66.7\%)$ than in the GP ABCF (31 months;
                      $5.6\%)$ group. Hence, the division of GP into GP ABCF vs DE
                      allows an optimized GP-based risk group discrimination in
                      NLPHL.},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40360880},
      doi          = {10.1038/s41375-025-02641-3},
      url          = {https://inrepo02.dkfz.de/record/301324},
}