%0 Journal Article
%A Ahmad, Shiekh Tanveer
%A Li, Yiran
%A Garcia-Lopez, Jesus
%A Gudenas, Brian L
%A Hadley, Jennifer
%A Paul, Leena
%A Wu, Stephanie C
%A Refaat, Alaa
%A Kojic, Marija
%A Batts, Melissa
%A Soliman, Taha
%A Pitre, Aaron
%A Arnskötter, Frederik
%A Zindy, Frederique
%A Jones, Alun
%A Twarog, Nathaniel R
%A Mayasundari, Anand
%A Bianski, Brandon
%A Tinkle, Christopher
%A Shirinifard, Abbas
%A Janke, Laura
%A Lu, Meifen
%A Lewis, Sara A
%A Onar-Thomas, Arzu
%A Pfister, Stefan M
%A Gajjar, Amar
%A Baker, Suzanne J
%A Roussel, Martine F
%A Rankovic, Zoran
%A Robinson, Giles W
%A Orr, Brent A
%A Wainwright, Brandon
%A Shelat, Anang A
%A Waszak, Sebastian M
%A Kutscher, Lena M
%A Lin, Hong
%A Northcott, Paul A
%T Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target.
%J Cancer cell
%V 43
%N 6
%@ 1535-6108
%C Cambridge, Mass.
%I Cell Press
%M DKFZ-2025-01007
%P 1141-1158.e11
%D 2025
%Z 2025 Jun 9;43(6):1141-1158.e11
%X Germline loss-of-function (LOF) variants in Elongator acetyltransferase complex subunit 1 (ELP1) are the most prevalent predisposing genetic events in childhood medulloblastoma (MB), accounting for ∼30
%K ELP1 (Other)
%K Elongator complex (Other)
%K Sonic hedgehog signaling (Other)
%K cerebellar development (Other)
%K childhood cancer predisposition (Other)
%K genetically engineered mouse models (Other)
%K granule neuron progenitors (Other)
%K in vivo preclinical studies (Other)
%K medulloblastoma (Other)
%K multi-omics (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40378836
%R 10.1016/j.ccell.2025.04.014
%U https://inrepo02.dkfz.de/record/301369