TY  - JOUR
AU  - Ahmad, Shiekh Tanveer
AU  - Li, Yiran
AU  - Garcia-Lopez, Jesus
AU  - Gudenas, Brian L
AU  - Hadley, Jennifer
AU  - Paul, Leena
AU  - Wu, Stephanie C
AU  - Refaat, Alaa
AU  - Kojic, Marija
AU  - Batts, Melissa
AU  - Soliman, Taha
AU  - Pitre, Aaron
AU  - Arnskötter, Frederik
AU  - Zindy, Frederique
AU  - Jones, Alun
AU  - Twarog, Nathaniel R
AU  - Mayasundari, Anand
AU  - Bianski, Brandon
AU  - Tinkle, Christopher
AU  - Shirinifard, Abbas
AU  - Janke, Laura
AU  - Lu, Meifen
AU  - Lewis, Sara A
AU  - Onar-Thomas, Arzu
AU  - Pfister, Stefan M
AU  - Gajjar, Amar
AU  - Baker, Suzanne J
AU  - Roussel, Martine F
AU  - Rankovic, Zoran
AU  - Robinson, Giles W
AU  - Orr, Brent A
AU  - Wainwright, Brandon
AU  - Shelat, Anang A
AU  - Waszak, Sebastian M
AU  - Kutscher, Lena M
AU  - Lin, Hong
AU  - Northcott, Paul A
TI  - Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target.
JO  - Cancer cell
VL  - 43
IS  - 6
SN  - 1535-6108
CY  - Cambridge, Mass.
PB  - Cell Press
M1  - DKFZ-2025-01007
SP  - 1141-1158.e11
PY  - 2025
N1  - 2025 Jun 9;43(6):1141-1158.e11
AB  - Germline loss-of-function (LOF) variants in Elongator acetyltransferase complex subunit 1 (ELP1) are the most prevalent predisposing genetic events in childhood medulloblastoma (MB), accounting for ∼30
KW  - ELP1 (Other)
KW  - Elongator complex (Other)
KW  - Sonic hedgehog signaling (Other)
KW  - cerebellar development (Other)
KW  - childhood cancer predisposition (Other)
KW  - genetically engineered mouse models (Other)
KW  - granule neuron progenitors (Other)
KW  - in vivo preclinical studies (Other)
KW  - medulloblastoma (Other)
KW  - multi-omics (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40378836
DO  - DOI:10.1016/j.ccell.2025.04.014
UR  - https://inrepo02.dkfz.de/record/301369
ER  -