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000301370 1001_ $$aSelvi, Saba$$b0
000301370 245__ $$aGenomic instability, DNA damage response and telomere homeostasis in pancreatic cancer.
000301370 260__ $$aLondon$$bAcademic Press$$c2025
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000301370 520__ $$aPancreatic cancer (PC) is becoming one of the most serious health problems at present, but its causes and risk factors are still unclear. One of the drivers in pancreatic carcinogenesis is altered genomic (DNA) integrity with subsequent genomic instability in cancer cells. The latter comprises a) DNA damage response and DNA repair mechanisms, b) DNA replication and mitosis, c) epigenetic regulation, and d) telomere maintenance. In our review we addressed the above aspects in relation to the most abundant and severe form of PC, pancreatic ductal adenocarcinoma (PDAC). In summary, the interactions between the DNA damage response, telomere homeostasis and mitotic regulation are not comprehensively understood at present, including the epigenetic factors entering the trait of genomic stability maintenance. In addition, the complexity of telomere homeostasis in relation to PDAC risk, prognosis and prediction also warrants further investigations.
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000301370 650_7 $$2Other$$aDNA damage
000301370 650_7 $$2Other$$aDNA repair
000301370 650_7 $$2Other$$aEpigenetic regulation of genome integrity
000301370 650_7 $$2Other$$aMitotic regulation
000301370 650_7 $$2Other$$aPancreatic Cancer
000301370 650_7 $$2Other$$aTelomere homeostasis
000301370 7001_ $$aReal, Carmen Macías$$b1
000301370 7001_ $$aGentiluomo, Manuel$$b2
000301370 7001_ $$aBalounova, Katerina$$b3
000301370 7001_ $$aVokacova, Klara$$b4
000301370 7001_ $$aCumova, Andrea$$b5
000301370 7001_ $$aMohlenikova-Duchonova, Beatrice$$b6
000301370 7001_ $$aRizzato, Cosmeri$$b7
000301370 7001_ $$aHalasova, Erika$$b8
000301370 7001_ $$aVodickova, Ludmila$$b9
000301370 7001_ $$aSmolkova, Bozena$$b10
000301370 7001_ $$0P:(DE-He78)19b0ec1cea271419d9fa8680e6ed6865$$aHemminki, Kari$$b11$$udkfz
000301370 7001_ $$aCampa, Daniele$$b12
000301370 7001_ $$aVodicka, Pavel$$b13
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